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MTOR phosphorylates AKT1. 30 / 30
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"One potential mechanism through which the mutations in mTOR (XREF_FIG) might increase S6K1 and Akt1 phosphorylation is by altering mTORC1 or mTORC2 assembly."
24631838
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"AST inhibited H. pylori -induced apoptosis by increasing the phosphorylation of AMPK and decreasing the phosphorylation of RAC-alpha serine/threonine protein kinase (Akt) and mTOR in H. pylori -stimulated cells."
32545395
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"IGF-1 promotes phosphorylation of protein kinase B (PKB and AKT) and mammalian target of rapamycin (mTOR), key intracellular signaling proteins that promote skeletal muscle growth and performance."
24704539
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"MTOR phosphorylates AKT1 at S473, and ASZ001 mouse BCC cells treated with itraconazole, a SMO inhibitor, reduces p-S473 AKT1 expression."
33617094
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"Chrysin induced ROS production, which lowered the phosphorylation of protein kinase B and the mammalian target of rapamycin (mTOR)."
34444754
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"It was previously demonstrated by our group (Pereira et al., 2012) that rapamycin inhibits formation of mTOR complex 1 (mTORC1) and 2 and insulin stimulated phosphorylation of p70S6K and protein kinas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23160140
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"Although Rictor T1135 phosphorylation leads to recruitment of 14-3-3 (XREF_SUPPLEMENTARY), it does not disrupt the mTORC2 complex nor does it significantly affect the ability of Rictor and mTOR to phosphorylate Akt1 in vitro (XREF_FIG)."
20832730
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"Thus, when AKT1 is correctly oriented at the cell membrane through its capacity to bind to PIP-3, AKT1 is phosphorylated by its activating kinases, PDPK-1 and mTOR complex 2 (mTORC2)."
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"Additionally, mTOR complex 2 can promote Akt1 phosphorylation, which promotes cardioprotection that is ablated by the mTOR inhibitor PP242, even in the presence of exogenous 50 µM NaHS [ xref ]."
30665344
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"The miR-17-92 cluster regulates PTEN expression and its downstream signaling pathway, which affects phosphorylation of protein kinase B (Akt), mechanistic target of rapamycin (mTOR), and glycogen synthase kinase 3 beta (GSK-3beta), and may underlie the differential therapeutic benefit of miR-17-92 augmented exosomes for stroke."
28232590
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"Sequentially, honokiol downregulated phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR) in neuro-2a cells."
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"MTOR exists in two complexes : mTOR Complex1, which is rapamycin sensitive and phosphorylates S6K1 and initiation factor 4E binding proteins (4E-BPs), and mTOR Complex2, which is rapamycin-insensitive and phosphorylates protein kinase B (PKB, also known as Akt)."
17452018
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"Furthermore, metformin suppressed the phosphorylation of Akt and protein kinase B (AKT) and mammalian target of rapamycin (mTOR) in response to pressure overload in wild type mice, but not in AMPKalpha2-/- mice."
21552292
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"The downstream insulin signaling was lower in OB than Con lambs as shown by reduction in the phosphorylation of protein kinase B, mammalian target of rapamycin, and 4-E binding protein 1."
21349823
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"Furthermore, Sal B increased stanniocalcin 1 (STC1) expression, induced the phosphorylation of protein kinase B (AKT) and mammalian target of rapamycin (mTOR) activity, enhanced cell migration, and activated VEGFR2/VEGFA signaling in endothelial cells."
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"However, the PI3K specific inhibitor (LY294002) inhibited CSF2 induced phosphorylation of ERK1/2 and MTOR as well as CSF2 induced phosphorylation of AKT1."
24520418
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"Subsequent analyses showed that Sb treatment decreased phosphorylation of protein kinase B (Akt) as well as the mammalian target of rapamycin (mTOR), while an Akt activator protected PC12 cells from autophagy."
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"MTOR was immunoprecipitated from PC3 from control cells or cells treated with siRNA to IKKalpha, and the ability of mTOR to phosphorylate recombinant Akt1 was analyzed."
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"The mTOR-rictor complex (mTORC2) phosphorylates AKT1 within the carboxy terminus at S473 and PDK1 phosphorylates AKT1 within its activation loop at T308 [ xref , xref ]."
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"This leads to activation of the PI3K signal transduction pathway with subsequent phosphorylation and activation of protein kinase B (PKB) and mammalian target of rapamycin (mTOR)."
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No evidence text available
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"Inhibiting the phosphorylation of PTEN weakened the proliferation and migration of estrogen induced-EOC cells estrogen and decreased the phosphorylation of Protein kinase B (AKT) and Mammalian target of rapamycin (mTOR)."
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"The alterations in the Ane-AA group were accompanied by hyperphosphorylation of protein kinase B and the mammalian target of rapamycin (mTOR)."
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"NAC also blunted the increase in phosphorylation of protein kinase B, mammalian target of rapamycin, p70 ribosomal S6 kinase, ribosomal protein S6, and mitogen activated protein kinase p38 at 2 and 8 d after exercise."
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"LA or Epo reduced the phosphorylation of the protein kinase B (Akt), a downstream target of phosphatidylinositol-3-kinases (PI3K), and mammalian target of rapamycin (mTOR) in ARPE-19 cells; by contrast, the induced changes of autophagy substrate, p62, showed biphasic pattern."
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"Although Phosphatidylinositide 3-kinase (PI3K)-dependent AKT1 phosphorylation by 3-Phosphoinositide Dependent Protein Kinase 1 (PDK1) and mTOR Complex 2 (mTORC2) has long been considered to be the primary mechanism accounting for AKT1 activation, these members are not sufficient enough to explain how AKT1 hyperactivation can occur in tumors with normal levels of PI3K and Phosphatase And Tensin Homolog (PTEN) activity [XREF_BIBR]."
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"Furthermore, 25 μM GEN reduced the levels of phosphorylation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR)."
34836271
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"Thus, protein kinase B (AKT) phosphorylation by mTOR mediated by phosphatidylinositol is central to insulin regulation (Mackenzie and Elliott, 2014)."
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"Protein Levels of Porcine beta-Defensin 2, Mammalian Target of Rapamycin, Phosphorylated Mammalian Target of Rapamycin, Protein Kinase B and Phorylated Protein Kinase B Concentrations in the Jejunal and Ileal Mucosa."
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"Neuroprotection by DZ was associated with increased phosphorylation of protein kinase B (Akt), mTOR, and the major mTOR downstream substrate, S6 Kinase (S6K)."
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