IndraLab

Statements

USP18 inhibits SGCG. 5 / 5
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"Indeed, IRF1 uniquely promotes the transcription of the negative regulator USP18 (Forero et al., 2019), which selectively inhibits type I IFN signaling without affecting IFN-λ signaling (Blumer et al., 2017)."
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"USP18 also interacts with IFNAR2 and STAT2 to block type I interferon signalling in a protease-independent manner."
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"In addition to its isopeptidase activity, USP18 negatively regulates type I and type III IFN signalling by blocking the IFNAR2 subunit of the interferon receptor 184 ."
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"CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.The IFN-stimulated gene ubiquitin-specific proteinase 18 (USP18) encodes a protein that negatively regulates T1 IFN signaling via stearic inhibition of JAK1 recruitment to the IFN-receptor 2 subunit (IFNAR2)."
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"Recent data by Zhang and coworkers (Malakhova et al., 2006) revealed, however, that USP18 attenuates JAK-STAT signaling, and thereby the type 1 IFN response, in a non-enzymatic manner, i.e., by directly competing with JAK1 for binding to the IFNAR2 subunit of the type 1 IFN receptor."
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