IndraLab

Statements

BCL6 inhibits BCL6. 14 / 16
| 12 2
reach
"Recently, it was reported that the acetylation of the proto-oncogene BCL6, which is a zinc finger transcription repressor, inactivates BCL6 [35]."
12878208
reach
"Together, these observations identified that loss of BCL6 directly relieves repression and potentiates PPARdelta mediated transactivation to restore fasting liver gene expression in Ppara -/-; Bcl6 LKO mice."
30983568
reach
"These data suggest that an interaction between Bcl6 and Prkd2 leads to Bcl6 phosphorylation, either directly by Prkd2 or via a Prkd2 kinase dependent event, thereby limiting Bcl6 access to the nucleus."
31980486
reach
"Moreover, ABC DLBCLs downmodulate BCL6 expression, likely as a result of their partial plasmacytic differentiation, thereby limiting the action of BCL6."
22224767
reach
"Third, overexpression of BCL6 in immortalized mouse mammary EpH4 cells blocked cellular differentiation and promoted proliferation, supporting a differentiation-suppressive role of BCL6 in mammary epithelial cells."
20124477
reach
"Together, these data support the hypothesis that T-bet is required to inhibit the modest amounts of Bcl-6 expressed in effector T H 1 cells to prevent Bcl-6 from dominantly repressing the expression of glycolysis pathway genes and that this activity is functionally important for promoting glycolysis in effector T H 1 cells."
25194422
reach
"Stat5 suppressed BCL6 expression in B-cell lymphomas, adipocytes and hepatocytes, but stimulated BCL6 in B lymphocytes and in insulin producing beta-cells during pregnancy."
20124477
sparser
"Bcl-6 protein inhibition of the Bcl6 gene instead depends on CtBP xref ( xref )."
20084069
reach
"Acetylation of BCL6 inhibits the ability of BCL6 to recruit HDAC containing SMRT co-repressor complexes [XREF_BIBR]."
26654227
reach
"Accordingly, the expression of Bcl6 and T-bet, lineage defining transcription factors for Tfh and Th1 cells, respectively, revealed a mild but significant trend toward increased Tbet and decreased Bcl6 in response to strong stimulation (XREF_FIG)."
33684030
sparser
"Importantly, Bcl-6 can be coexpressed with Foxp3 as it seems Foxp3 expression is not inhibited by Bcl-6."
23056063
reach
"Strikingly, a bifurcation between Tfh and effector Th cells was measurable by the second cell division of CD4 + T cells, at day 2 after an acute viral infection : IL2Ralpha int cells expressed Bcl6 and CXCR5 (Tfh cell program), whereas IL2Ralpha hi cells exhibited strong Blimp1 expression that repressed Bcl6 (effector Th cell program)."
21636296
reach
"Recent studies suggest that the transcriptional co-activator p300 acetylates BCL-6 and, in doing so, disrupts the ability of BCL-6 to recruit HDACs, thereby compromising its ability to repress transcription and induce cell transformation."
| PMC
reach
"As a consequence of the mutations, CREBBP and EP300 lose their ability to acetylate BCL-6 and p53, a post-translational modification that inactivates BCL-6 by disrupting the recruitment of histone deacetylases (HDACs) and thus hindering its capacity to repress transcription, while representing an essential requirement for p53 activation XREF_BIBR - XREF_BIBR."
21842702