IndraLab

Statements

USP4 activates USP4. 4 / 6
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reach
"Ubiquitination of USP4 could physically block its interaction with CtIP or induce conformational change of USP4."
26387952
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"Ectopic expression of sh-RNA-resistant USP4 reverses the effect of USP4 knockdown."
21331078
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"Together, these findings provided support for USP4 interactions with CtIP and MRN being critical for its DDR functions and for a model wherein USP4 auto-deubiquitylation promotes these interactions and thereby USP4 functions in DSB repair."
26455393
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"Furthermore, gastrodin significantly upregulated the expression of USP4 and increased the binding of USP4 to the insulin receptor.Considering the importance of the PI3K-Akt pathway in the pathogenesis of T2DM, we detected the effects of gastrodin on the PI3K-Akt pathway to further explore the underlying mechanism of gastrodin in ameliorating insulin resistance."
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