IndraLab

Statements

USP17L2 increases the amount of BRD4. 5 / 5
| 5
reach
"To test this hypothesis, we co-expressed DUB3 with BRD4 in 293T cells and found that DUB3 increased BRD4 protein expression in a dose dependent manner."
30057199
reach
"Moreover, knockdown of DUB3 largely decreased BRD4 protein levels, but little or no further reduction in BRD4 protein expression by co-treatment with PD0332991 was observed."
30057199
reach
"Accordingly, DUB3 knockdown decreased BRD4 protein levels in F133V expressing cells, and this effect was blocked by MG132."
30057199
reach
"In an array of cancer cell lines, we demonstrated that knockdown of DUB3 by shRNAs largely decreased BRD4 protein levels, but not at mRNA levels."
30057199
reach
"Unexpectedly, knockdown of DUB3 not only decreased BRD4 protein levels in SPOP F133V expressing DU145 cells but also sensitized SPOP-F133V cells to JQ1 treatment, suggesting the presence of a SPOP ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199