Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified COPS6 decreases the amount of MYC. 2 / 2

| 2

➶

reach

"Overexpression of CSN6 increased the mRNA levels of Myc transcriptional targets (CDC25A, cyclin D1, and Tert) and decreased the mRNA levels of Myc transcriptionally repressed genes (p27Kip1, CDKN2B, and p21Cip1), while loss of CSN6 reversed the expression of these Myc target genes."

25395170

➶

reach

"Overexpression of CSN6 reduced the protein levels of Fbxw7alpha and increased Myc protein levels; while CSN6 knockdown by shRNA resulted in increased protein levels of Fbxw7alpha and decreased protein levels of Myc in two cell lines HCT116 and U2OS cells (XREF_FIG)."

25395170

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...