IndraLab

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USP15 deubiquitinates KEAP1. 4 / 4
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"USP15 deubiquitinates Keap1."

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"Here we report that the deubiquitinating enzyme, USP15, specifically deubiquitinates Keap1, which suppresses the Nrf2 pathway."

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"USP15 activates ubiquitin ligase activity by deubiquitinating Keap1 as its adaptor, promoting the proteasomal degradation of Nrf2."