IndraLab

Statements

FGF13 binds SCN9A. 5 / 7
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"Our immunohistochemical data show colocalization of FHF2A with Nav1.7 in small diameter DRG neurons, most of which are nociceptors, and immunoprecipiation experiments revealed an interaction between FHF2 and Nav1.7 in HEK293 cells, supporting the conclusion that the two proteins may interact in vivo."
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"These results suggest that increased DRG neuron excitability after nerve injury might occur in part via a Nav1.7-FHF2 mediated mechanism."
36222860
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"We have previously demonstrated that FHF2 interacts with Nav1.7 and that knockdown of FHF2A or FHF2core (all isoforms of FHF2) in DRG neurons results in gain-of-function changes in the gating properties of Nav1.7."
36222860
sparser
"Our data suggest that increased neuronal excitability after nerve injury might be triggered, in part, via a loss of FHF2-Nav1.7 interaction."
36222860
sparser
"In this study we investigated whether this interaction between FHF2 and Nav1.7 translates to increased excitability in DRG neurons."
36222860