IndraLab

Statements

SCN9A binds FGF13. 6 / 7
1 | 1 4
sparser
"In this study we investigated whether this interaction between FHF2 and Nav1.7 translates to increased excitability in DRG neurons."
36222860
sparser
"Our data suggest that increased neuronal excitability after nerve injury might be triggered, in part, via a loss of FHF2-Nav1.7 interaction."
36222860
sparser
"We have previously demonstrated that FHF2 interacts with Nav1.7 and that knockdown of FHF2A or FHF2core (all isoforms of FHF2) in DRG neurons results in gain-of-function changes in the gating properties of Nav1.7."
36222860
signor
"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."
20679355
sparser
"These results suggest that increased DRG neuron excitability after nerve injury might occur in part via a Nav1.7-FHF2 mediated mechanism."
36222860
reach
"Our immunohistochemical data show colocalization of FHF2A with Nav1.7 in small diameter DRG neurons, most of which are nociceptors, and immunoprecipiation experiments revealed an interaction between FHF2 and Nav1.7 in HEK293 cells, supporting the conclusion that the two proteins may interact in vivo."
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