IndraLab

Statements

USP14 binds AR. 19 / 23
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"35 The AR dependent cell cycle arrest by inhibiting USP14 prompted us to investigate the interaction between USP14 and AR."
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"More importantly, we observed that USP14 could bind to AR and decreased AR ubiquitination, suggesting that USP14 may be another DUB of AR (XREF_FIG)."
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"We found that USP14 does not interact with AR in the nucleus under DHT stimulation (Fig. xref )."
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"To detect the interaction between AR protein and USP14 protein, we performed co-IP for USP14 and AR."
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"We found that (i) USP14 could bind to AR, and additionally, both genetic and pharmacological inhibition of USP14 accelerated the ubiquitination and degradation of AR; (ii) downregulation or inhibition of USP14 suppressed cell proliferation and colony formation of LNcap cells and, conversely, overexpression of USP14 promoted the proliferation; and (iii) reduction or inhibition of USP14 induced G0/G1 phase arrest in LNcap prostate cancer cells."
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"More importantly, we observed that USP14 could bind to AR and decreased AR ubiquitination, suggesting that USP14 may be another DUB of AR ( xref )."
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"The AR-dependent cell cycle arrest by inhibiting USP14 prompted us to investigate the interaction between USP14 and AR."
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"Our research confirms that KDM4A-AS1 may inhibit the ubiquitin-mediated degradation process by stabilizing the binding of USP14 to AR or AR-Vs and leading to enzalutamide resistance in CRPC cell lines."
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"We found that USP14 could directly bind AR proteins (XREF_FIG)."
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"In conclusion, this work has provided novel insights into the interaction between proteasome-associated DUB USP14 and AR, and the functional role of deubiquitination of AR by USP14 in AR-positive human breast cancer cells including TNBC."
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"For example, USP14 interacts with androgen receptor (AR) to regulate the progression in prostate cancer and breast cancer xref , xref ."
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No evidence text available
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"Our research confirms that KDM4A-AS1 may inhibit the ubiquitin-mediated degradation process by stabilizing the binding of USP14 to AR or AR-Vs and leading to enzalutamide resistance in CRPC cell lines."
34759344
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"KDM4A-AS1 inhibits AR degradation by stabilizing USP14- AR complex."
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"Additionally, we sought to determine that whether USP14 directly interacts with AR and serves as another DUB for AR or promotes the transcription of AR."
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"We found that USP14 could directly bind AR proteins ( xref )."
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"To determine the interaction between AR and USP14 protein in the nucleus, we performed co-IP for AR and USP14 using both nuclear and cytosolic preparations of MDA-MB-453 cells treated with DHT or control solvent for 24 h."
29353883
sparser
"Additionally, we sought to determine that whether USP14 directly interacts with AR and serves as another DUB for AR or promotes the transcription of AR."
28151478
biogrid
No evidence text available
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