IndraLab

Statements

BRAF binds KRAS and NRAS. 7 / 7
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"At present, KRAS , NRAS , and BRAF mutations are associated with poorer outcomes in metastatic CRC, both in surgical and nonsurgical patients."
27069739
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"We now show the MAPK-ERK genes, BRAF, KRAS and NRAS (collectively representing 12.2% of patients) are also independently associated with short OS in a cohort of patients requiring treatment."
32015491
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"The detection of a KRAS, NRAS or BRAF gene mutation was associated with a trend towards shorter overall survival compared to when no mutations were detected by the MS test (Figure xref )."
29254176
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"Studies have identified several genetic alterations, including KRAS, NRAS and BRAF mutations, which are associated with resistance to anti-EGFR agents."
29285234
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"The detection of a KRAS, NRAS or BRAF gene mutation was associated with a trend toward shorter duration of benefit from EGFR-TKI treatment compared to when no mutations were detected by the MS test (Figure xref )."
29254176
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"KRAS, NRAS, and BRAF mutations are associated with sensitivity to MEK inhibitors, but EGFR mutations are not (Fig.  xref c)."
26220863
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"The eighth edition of the AJCC Cancer Staging System is focused on the individual treatment and prognostic factors of CRC based on molecular biomarkers, such as BRAF , KRAS , and NRAS that are associated with chromosomal instability, mismatch repair, and microsatellite instability [ xref ]."
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