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UCHL5 leads to the deubiquitination of FASN. 2 / 2
| 2

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"Mechanistically, on the one hand, the accumulation of FASN is caused by the enhanced deubiquitination of FASN mediated by UCHL5 (ubiquitin c-terminal hydrolase L5)."

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"It was found that UCHL5 inhibited both K48 and K63-linked ubiquitination of FASN (Fig. 4H)."