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AKT1S1 activates MTOR. 34 / 34
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"The induced phosphorylation of PRAS40 has been posited to increase mTOR activity [XREF_BIBR; XREF_BIBR]."
20127721
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"Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR."
17277771
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"When viewed in this light, our results suggest that phosphorylation of PRAS40 at T246 may not be essential, or at least not sufficient to positively regulate mTOR activity and protein synthesis."
20127721
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"For instance, protein levels of p-P70S6K and p-S6 in the mTOR pathway were shown to be decreased in PRAS40 KO mice (XREF_FIG), but these two proteins were not examined in PRAS40 transfected brains, even though we have shown that PRAS40 vector transfection promoted mTOR activity (XREF_FIG)."
24583056
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"PRAS40 knockdown could inhibit the activities of the mTOR pathway; moreover, neuronal autophagy and apoptosis were exacerbated by PRAS40 knockdown."
34900085
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"Binding of PRAS40 to the mTORC1 signaling complex attenuates mTOR ac-tivity, presumably by inhibition of downstream substrate binding; however, phosphorylation of the Thr246 residue by Akt and PKB rel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20019839
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"XREF_BIBR, XREF_BIBR Nevertheless, considerable evidence exists to show that insulin can enhance the activation of mTOR via stimulation of 4EBP1 binding to dimeric mTOR complex 1, XREF_BIBR and mediated by the Akt and PKB substrate PRAS40 (proline rich Akt and PKB substrate 40 kDa)."
25914534
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"Both kinases phosphorylate proline rich-AKT substrate 40 (PRAS40), which increases mTOR kinase activity on dissociation from mTORC1."
29401696
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"Intriguingly, while the levels of p-AKT (serine 473) remained unchanged, the levels of p-GSK3beta, p-PRAS40 and p-AKT substrates increased markedly in L-Atg5 and mTOR DKO livers (XREF_FIG)."
31095752
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"Given these data and the role of PRAS40 in insulin signaling, it is tempting to speculate that Abeta accumulation increases PRAS40 phosphorylation, which in turn leads to chronic hyperactive mTOR and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29729422
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"PRAS40 increases the activation of mTOR pathway in ESFT cells and glomerular mesangial cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28978182
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"In contrast, other studies have reported that PRAS40 is essential to induce mTOR activity, and that silencing PRAS40 impairs the phosphorylation of 4E-BP1 and S6, two of mTOR 's downstream proteins."
24583056
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"In addition, metformin suppressed the proliferation of glioma cells through PRAS40 mediated mTOR inhibition independent of AMPK [XREF_BIBR]."
33578894
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"We propose that active GSK3α/β cooperates with mTOR activator PRAS40 or p70 s6 kinase for the regulation of AKT/mTOR signaling pathway, and altogether these regulators inhibit autophagy by inhibition of AKT and restriction of mTOR activation."
34482378
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"In a recent report, inhibition of mTOR signalling by the overexpression of PRAS40 prevented the development of cardiomyopathy in high-fat diet fed mice [XREF_BIBR]."
24997452
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"PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR providing PRAS40 as an important regulator of insulin sensitivity and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21906675
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"Phosphorylation of PRAS40 by Akt can block the activity of this substrate, lead to its dissociation from mTORC1 to promote mTOR activation and prevent apoptosis."
24712647
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"AKT1 is one of the downstream targets of PIK3, which phosphorylates AKT1S1 and relieves AKT1S1 mediated MTOR inhibition 60."
29749377
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"Following phosphorylation of PRAS40 by Akt, PRAS40 can dissociate from mTORC1 to promote mTOR activation and prevent apoptosis."
25105207
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"Upon phosphorylation, PRAS40 dissociates from the mTOR complex and increases mTOR kinase activity."
19276681
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"Akt mediated phosphorylation of PRAS40 induces mTOR activation XREF_BIBR."
27313493
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"In summary, our study identifies that phosphorylation of PRAS40 may lead to the activation of mTOR signaling pathway in CNI induced rapid progression of human renal cancer."
21886838
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"Silencing of PRAS40 by small interfering RNA suppresses the mTOR pathway signaling in response to insulin treatment in HEK293 cells, adipocytes, liver cancer cells and ESFT cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28978182
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"PRAS40 KD increased the association of mTOR with p-raptor (XREF_FIG)."
20127721
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"1 PRAS40 is known to inhibit mammalian target of rapamycin C1 (mTORC1) activity by binding Raptor and competing away binding of the mTOR substrates 4E-BP1 and p70S6K."
28945219
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"The results indicated that increased p-PRAS40 expression could activate the mTOR pathway to decrease the level of autophagy."
32855714
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"Several substrates overlap with AKT and mTOR signaling, including PRAS40 [XREF_BIBR], TSC2 [XREF_BIBR], 4EBP1 [XREF_BIBR], and EIF4B [XREF_BIBR - XREF_BIBR]."
27270648
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"In fact, the observed decreases in eIF4E and several other proteins necessary for mTOR signaling such as Raptor, PRAS40, cyclin D1, and stearoyl CoA desaturase (SCD) a key enzyme in fatty acid synthesis, suggest reduction in mTOR associated cell proliferation and growth [XREF_BIBR, XREF_BIBR]."
26276744
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"Under some circumstances, studies suggest that over-expression of PRAS40 that simultaneously activates Akt and mTOR but blocks forkhead transcription factor activity can lead to neuronal protection during ischemic induced oxidative stress ( xref )."
25105207
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"Some of these proteins that mediate mTOR signaling such as Raptor, Rictor, PRAS40, mSin1, FKBP38, and IRS-1 may represent therapeutic targets affected by the recent development of small molecule mTOR [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26003731
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"PRAS40 phosphorylation promotes the activation of mTOR signaling pathway."
28978182
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"Although Akt has many substrates within the cell, phosphorylation of two substrates, TSC2 and PRAS40, leads to activation of mTOR."
19166931
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"Our studies highlight EPO and PRAS40 signaling in the mTOR pathway as potential therapeutic strategies for development against degenerative disorders that lead to cell demise."
23029019
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"The phosphorylation of PRAS40 results in its dissociation from mTORC1 and enhanced mTOR activation."
27086010