IndraLab

Statements

SCN8A leads to the deubiquitination of TRAF6. 7 / 7
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"Furthermore, MED also markedly suppressed the ubiquitination of TRAF6 in vitro ubiquitination system (XREF_FIG)."
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"MED suppressed the polyubiquitination of TRAF6, but did not affect TRAF6 dimerization and IRAK1 phosphorylation, suggesting that TRAF6 could be the target of MED in response to LPS."
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"MED significantly inhibited TAK1 phosphorylation and TRAF6 polyubiquitination, but not IRAK1 phosphorylation and TRAF6 dimerization, indicating that MED inhibits LPS induced inflammatory responses at least in part through suppression of TRAF6 polyubiquitination."
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"Indeed, we found that MED significantly blocked the ubiquitination of TRAF6 and IkappaBalpha (XREF_FIG and XREF_SUPPLEMENTARY) in HEK 293T cells without LPS treatment, indicating that MED can inhibit protein ubiquitination independently on TLR4 signaling."
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"As shown in XREF_FIG, MED blocked the ubiquitination of TRAF6 in a dose dependent manner."
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"To determine whether MED can inhibit the ubiquitination of TRAF6 independently on TLR4 signaling, we performed the ubiquitination assays in 293T cells without LPS treatment."
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"MED inhibited not only polyubiquitination of TRAF6 but also polyubiquitination mediated degradation of IRAK1 and IkappaBalpha induced by LPS, implicating that MED may serve as an ubiquitination inhibitor to inhibit the ubiquitination of proteins involved in TLR4 pathway."
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