IndraLab

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YTHDF1 activates USP14. 5 / 5
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"Intersection assays revealed that YTHDF1 promoted USP14 protein translation in an m 6 A dependent manner."
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"Previous studies have reported that YTHDF1 promotes the occurrence and metastasis of gastric cancer in an m6A-dependent manner by promoting the translation of USP14 and it may represent a potential target for gastric cancer treatment (Chen et al. 2021c)."
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"We herein found that YTHDF1 could promote USP14 protein translation in a m 6 A dependent manner and USP14 overexpression reversed the tumor suppressive effects caused by YTHDF1 knockdown in GC cells."
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"We found that knockdown of YTHDF1 decreased the protein abundance of USP14 rather than its transcription levels in AGS and BGC-823 cells as expected by RT-qPCR and western blotting analysis (XREF_FIG)."
33791305
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"Our findings indicated that YTHDF1 could promote USP14 protein translation in a m 6 A dependent manner, leading to gastric carcinogenesis (XREF_FIG)."
33791305