IndraLab

Statements

YTHDF1 activates USP14. 14 / 14
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"Mechanically, YTHDF1 promoted tumor progression and metastasis of GC by promoting USP14 translation [53]."
36707507
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"Our findings indicated that YTHDF1 could promote USP14 protein translation in a m 6 A dependent manner, leading to gastric carcinogenesis (XREF_FIG)."
33791305
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"YTHDF1 has been demonstrated to promote the metastasis of gastric cancer in an m6A-dependent way by promoting USP14 translation [34]."
38042806
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"In addition, our previous studies uncovered that YTH N 6 -methyladenosine RNA binding protein 1 (YTHDF1) as an m 6 A reader promotes gastric tumorigenesis by enhancing ubiquitin specific peptidase 14 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38729588
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"YTHDF1-mediated m6A facilitates USP14 protein, thus, boosting GC cell proliferation, invasion, gastric tumorigenesis, and lung metastasis [95]."
37443100
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"YTHDF1 could promote the translation of USP14 protein, which then promoted the tumorigenesis and metastasis of GC (109, 137)."
36561529
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"We found that knockdown of YTHDF1 decreased the protein abundance of USP14 rather than its transcription levels in AGS and BGC-823 cells as expected by RT-qPCR and western blotting analysis (XREF_FIG)."
33791305
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"Previous studies have reported that YTHDF1 promotes the occurrence and metastasis of gastric cancer in an m6A-dependent manner by promoting the translation of USP14 and it may represent a potential target for gastric cancer treatment (Chen et al. 2021c)."
34677810
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"Other examples of the pro-metastatic role of YTHDF1 by promoting gene translation have been described, including YTHDF1-mediated increased translation of USP14 in gastric cancer [249], ARHGEF2 in CRC [250], FOXM1 and PKM2 in breast cancer [251, 252], PLK1 in prostate cancer [253], SLP2 and ANLN in HCC [254, 255], DDX23 in pancreatic ductal adenocarcinoma [256], and HRAS in various cancers [257]."
37369946
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"In addition, Ubiquitin-specific protease 14 (USP14) translation was reported to be upregulated by YTH N6-Methyladenosine RNA Binding Protein 1 (YTHDF1), resulting in carcinogenesis and unfavorable outcome for gastric cancer patients (29)."
36875073
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"YTHDF1 also promotes Ubiquitin-specific protease 14(USP14) and frizzled homolog 7(FDZ7) protein translation in m 6 A-dependent manner as well as activating the Wnt/β-Catenin pathway, which promotes ga[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35341774
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"Intersection assays revealed that YTHDF1 promoted USP14 protein translation in an m 6 A dependent manner."
33791305
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"We herein found that YTHDF1 could promote USP14 protein translation in a m 6 A dependent manner and USP14 overexpression reversed the tumor suppressive effects caused by YTHDF1 knockdown in GC cells."
33791305
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"Chen et al. [37] identified that USP14 was a downstream target of YTHDF1, which could promote USP14 protein translation in a m6A-dependent manner."
39009956