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"To further dissect these findings , siRNAs were transfected into cells to knock down the transcription factor p65 in the presence of Casp8 , and the Western blot results indicated that decreased p65 impeded A20 expression ( Figure 3G , lane 1 and lane 3 ) and abrogated Casp8-induced A20 upregulation ( Figure 3G , lanes 1-4 ; Figure S3D ) ."