IndraLab

Statements

DVL binds CYLD. 5 / 5
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"For instance, CYLD interacts with Dishevelled (DVL) and counteracts its K63-linked ubiquitination, leading to inhibition of this cytoplasmic effector in the Wnt/β-catenin pathway ( xref )."
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"The deubiquitinating enzyme CYLD binds to and deubiquinates Dvl, inhibiting the signaling activity of Dvl and the activation of the Wnt pathway."
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"At the molecular level, we show that CYLD interacts with Dvl and regulates K63-linked ubiquitination of the polymerization-prone DIX domain of Dvl."
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"CYLD interacts with Dvl and edits its ubiquitin chains, supporting a model in which the effect of CYLD on Wnt signaling is mediated by CYLD dependent deubiquitination of Dvl.How does Dvl function depe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
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