IndraLab

Statements

TP53 binds CDKN2A and MDM2. 34 / 34
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"Interestingly, Plk1 is involved in many regulatory feedback loops that are associated with p53, MDM2 and p16 INK4A /p14 ARF (reviewed in depth in [ xref ]) and with up to 84% of human melanomas expressing wild-type p53, the reactivation of p53 signaling would provide a distinct advantage in the remediation of melanomas with diverse mutational backgrounds [ xref ]."
27793694
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"Recent evidence suggests that E2F1 is also capable of initiating apoptosis by directly inducing the expression of CDKN2A , which forms a complex with MDM2 and p53 to initiate cell-cycle arrest and apoptosis [ xref , xref ]."
31722751
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"It has been shown to bind to multiple proteins, p14 ARF , p53 and HDM2 of ARF-p53-p21 tumor suppressor axis, and control cancer cell proliferation in two directions in a dose dependent way xref xref xref ."
27457128
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"The nucleoplasmic p14ARF promotes formation of the p14ARF-p53-HDM2 ternary complex and inhibits the nuclear export and p53-ubiquitination activity of HDM2, thereby stabilizing and activating p53."
26119940
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"In cells that harbour wild type p53, p14ARF can associate with p53 bound HDM2 forming tri-molecular complexes [ xref , xref ]."
12685933
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"One possible reason might be that p14ARF could bind to HDM2 in both nucleolus and nucleoplasm, xref , xref so that the SOX6-induced translocation of p14ARF could increase the formation of p14ARF-HDM2-p53 ternary complex but not affect the ability of p14ARF to bind with HDM2."
26119940
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"Association of p14 ARF , p53 and Hdm2 with clinicopathological factors."
15318938
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"P14 protein interacts physically with MDM2 and stabilises the p53 protein in the nucleus by blocking its cytoplasmic transport and MDM2-mediated degradation, indicating that it acts as an upstream reg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18410922
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"To gain insight into the mechanistic basis for the functional link between p19 and the p53 pathway, coimmunoprecipitation experiments were performed to assess potential physical interactions between p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9529248
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"In addition, MDM2 and p14 ARF not only interact with p53 but also interact with other important cellular proteins, including Rb, ATM, and E2F/DP1, to exert their oncogenic and tumor suppressor function, respectively xref , xref ."
23145162
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"Numerous studies have demonstrated that the tumor suppressor protein p14ARF can stabilize and activate p53 by inhibiting the E3 ligase activity and nuclear export of HDM2, which is followed by formation of the p14ARF-HDM2-p53 ternary complex. xref , xref , xref , xref , xref , xref Consistent with those reports, we found that SOX6 can trigger formation of the p14ARF-HDM2-p53 ternary complex via induction of translocation of p14ARF from the nucleolus to the nucleoplasm."
26119940
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"Molecular interactions between p53, MDM2, and p14ARF fastidiously regulate the balance between the synthesis and turnover of p53, and thus, control the progression of the cell cycle."
31692772
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"Furthermore, NPM1 has been shown to interact with HDM2, p53, and ARF, and can exert either a positive or negative influence on cellular growth by regulating the activities of these proteins ( xref ; xref )."
29940189
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"We report that the inhibition of the Mdm2-mediated degradation of p53 by p14ARF is associated with a decrease in the proportion of ubiquitinated p53."
11526482
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"P14ARF (p19 in mice) forms a ternary complex with MDM2 and p53, leading to antagonism of the MDM2-mediated ubiquitination of p53 [ xref ]."
19538162
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"Thus, our data strongly suggest that SOX6 may promote formation of the p14ARF-HDM2-p53 ternary complex."
26119940
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"It binds to p14ARF-hMDM2-p53 complexes."
19323829
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"Numerous studies have demonstrated that the tumor suppressor protein p14 ARF can stabilize and activate p53 by inhibiting the E3 ligase activity and nuclear export of MDM2, which is followed by formation of the p14ARF-MDM2-p53 ternary complex [ xref – xref ]."
30651135
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"In the order hand, p14 ARF   interacts with MDM2 and blocks MDM2 to target p53 to degradation, contributing with p53 stabilization."
21860617
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"In vitro , nuclear p14 ARF binds Hdm2 to block Hdm2-dependent nucleocytoplasmic shuttling of p53, which is required before cytoplasmic degradation of p53."
15318938
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"In these HL samples and the L428 cell line, nucleolar p14 expression was associated with nucleoplasmic overexpression of p53 and Hdm2 proteins."
11839577
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"P14 ARF binds and inhibits the p53 antagonist Mdm2, leading to the accumulation of p53 [ xref ]."
28881591
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"Co-immunoprecipitation and immunocytofluorescence assays demonstrated that SOX6 can promote formation of the p14ARF-HDM2-p53 ternary complex by promoting translocation of p14ARF (p14 alternate reading frame tumor suppressor) to the nucleoplasm, thereby inhibiting HDM2-mediated p53 nuclear export and degradation."
26119940
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"P14 ARF (the alternative product of the INK4 gene) interacts with MDM2, preventing association of p53 and MDM2 and thereby stabilising p53."
12618194
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"Further support that p19 and p53 interact with nonoverlapping regions of MDM2 comes from the observations that p19 and p53 can coexist in MDM2 complexes and that p53 immunoprecipitations followed by W[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9529248
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"Previous studies have revealed that the p14 alternate reading frame tumor suppressor (p14ARF) is capable of inhibiting the nuclear export and p53-ubiquitination activity of HDM2, as well as increasing the stability of the p53 protein by forming the p14ARF-HDM2-p53 ternary complex. xref , xref , xref To test whether SOX6 can promote formation of the p14ARF-HDM2-p53 complex, HeLa SOX6-tet cells were co-transfected with pLex-p14ARF-myc and pLex-HDM2-V5 plasmids, and the cell lysates were subjected to co-immunoprecipitation assay."
26119940
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"SOX6 promotes formation of the p14ARF-HDM2-p53 ternary complex by inducing translocation of p14ARF to the nucleoplasm."
26119940
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"Collectively, our data indicate that SOX6-mediated NPM1 downregulation is at least one pathway contributing to translocation of p14ARF and to formation of the p14ARF-HDM2-p53 ternary complex."
26119940
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"Li et al. recently showed in nasopharyngeal carcinoma cell lines that UCHL1 was a member of the p53, p14ARF, and MDM2 complex XREF_BIBR."
22028813
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"Our findings indicate that expression of the p53, p14ARF, and HDM2 genes are associated with CLL."
22047081
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"EBNA-LP can interact with a complex of the tumor suppressors MDM2, p53 and the cyclin-dependent kinase inhibitor p14 ARF [ xref ], which could influence both proliferation and apoptosis responses."
29462212
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"XREF_BIBR, XREF_BIBR, XREF_BIBR To test whether SOX6 can promote formation of the p14ARF, HDM2, and p53 complex, HeLa SOX6-tet cells were co-transfected with pLex-p14ARF-myc and pLex-HDM2-V5 plasmids, and the cell lysates were subjected to co-immunoprecipitation assay."
26119940
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"Importantly, the SOX6ΔHMG mutant showed a loss of ability to induce the nucleoplasmic translocation of p14ARF as well as of the subsequent formation of p14ARF-HDM2-p53 ternary complex, thereby abolishing the effect of SOX6 on p53 activation."
26119940
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"We next investigated the mechanism by which SOX6 promotes formation of the p14ARF-HDM2-p53 ternary complex."
26119940