IndraLab

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CYLD inhibits MAPK. 5 / 7
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"Recently, we, along with others, have demonstrated that CYLD also inhibits MAPKs including p38 and JNK xref – xref ."
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"When transfected in cell lines, CYLD inhibits the activation of NF-kappaB and mitogen activated protein kinases stimulated by innate immune receptors, such as the Toll like receptors and TNF receptors."
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"CYLD was shown to negatively regulate NF-kappaB and MAPK activation by removing ubiquitin chains from key signalling molecules including NEMO, TRAF2, TRAF6 and RIPK1."
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"Moreover, knockdown of CYLD enhanced mitogen activated protein kinase (MAPK) ERK- and p38 mediated expression of c-jun, c-fos, and c-myc, which govern Nrf2 expression in cardiomyocytes."
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"CYLD also negatively regulates the c-Jun N-terminal kinase (JNK) signaling pathway and mitogen activated protein kinase (MAPK) pathway, which are known to participate in a wide range of cellular processes, including proliferation, differentiation, and apoptosis of cholesteatoma [XREF_BIBR, XREF_BIBR]."
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