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TNFAIP3 activates apoptotic process. 28 / 29
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"miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus related hepatocellular carcinoma."
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"TNFAIP3 can increase apoptosis by inhibiting the expression of Bcl-2 transcription factor NF-kappaB ."
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"After experiments and analysis, the conclusion of this study demonstrated that TNFAIP3 stimulated inflammatory response, apoptosis, and oxidative stress in vivo and in vitro by activating RIP3/NLRP3 a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TNF-alpha-induced-protein 3 (encoded by TNFAIP3) and its interacting protein, TNFAIP3 interacting protein 1 (encoded by TNIP1), are both key regulators of the NFkappaB signaling pathway (XREF_FIG), and modulate cell activation, cytokine signaling and apoptosis."
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"Accordingly, overexpression of an miR-29b-refractory isoform of TNFAIP3 restored NF-kappaB and extrinsic apoptosis, confirming that TNFAIP3 is a functionally relevant target of miR-29b."
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"It was found that TNFAIP3 impeded cell proliferation and migration, and enhanced apoptosis of OCI-LY3 cells."
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"Based on the flow cytometry result, the overexpression of YTHDF2 and TNFAIP3 or the overexpression of YTHDF2 with JSH‐23 treatment increased apoptosis of T98G and LN229 cells under TMZ treatment, whereas the knockdown of YTHDF2 and TNFAIP3 reduced apoptosis of T98G/TR and LN229/TR cells, and the knockdown of YTHDF2 and TNFAIP3 with JSH‐23 treatment reversed this result (Figure 6g, h)."
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"A20 Like CYLD , A20 suppresses cell proliferation and promotes apoptosis as a negative regulator of the NF-kappaB pathway , and it is well known to play an important role in inflammation and immunity ( Dixit et al. 1990 ; Hoesel and Schmid 2013 ) ."
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"TNFAIP3, that was found to be up-regulated by TRAIL in our study, is an inhibitor of the NFKB pathway [XREF_BIBR] and may thereby promote apoptosis but, on the other hand, it was shown to decrease TNF mediated apoptosis and necrosis [XREF_BIBR], leaving its specific influence unclear."
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"In KRAS (G12V)-transduced bronchial epithelial (BEAS-2B) cells, introduction of anti-miR-29b constructs increased the sensitivity to apoptosis by targeting TNFAIP3 and A20, a negative regulator of nuclear factor (NF)-kappaB signaling."
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"We also found shared upregulation of genes involved in apoptosis and B-cell activation including TNFAIP3, XAF1, and LCP1, as well as ADAR, which has been implicated in viral RNA replication (Zhu et al., 2020)."
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"Accordingly, overexpression of a miR-29b-refractory isoform of TNFAIP3 restored NF-kappaB and extrinsic apoptosis, confirming that TNFAIP3 is a functionally relevant target of miR-29b."
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"TNFAIP3 protein as a zinc finger protein and ubiquitin shearing enzyme can suppress activated NF-kappaB signal pathway and induce apoptosis of TNF by activating ubiquitin ligase and ubiquitinase."
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"In addition, TNFAIP3 re-expression can inhibit proliferation, decrease expression of target genes in NF-kappaB signaling pathway, increase cytotoxicity and induce apoptosis in cells lacking TNFAIP3."
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"For instance, TNFAIP3 enhances the resistance of various cell types, including intestinal epithelial cells, liver cells and pancreatic beta cells, to the apoptosis induced by TNF-α ( Catrysse et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Functional reconstitution of TNFAIP3 in TNFAIP3-null DLBCL causes apoptosis and growth arrest, supporting a tumor suppressor role in DLBCL ."
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"Moreover, TNFAIP3 induces cell growth arrest and apoptosis, accompanied by down-regulation of nuclear factor-kappa B (NF-kB) activation [XREF_BIBR, XREF_BIBR]."
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"Results demonstrated that TNFAIP3 knockdown contributed to the proliferation, migration, invasion, and inflammation and suppressed the apoptosis in HAND2-AS1-overexpressed MH7A cells."
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"The deletions or mutations of TNFAIP3 are found in about 30% of patients with diffuse large B-cell lymphoma, while reinforced TNFAIP3 induces apoptosis and cell growth arrest XREF_BIBR, suggesting TNFAIP3 is a tumor suppressor."
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"TNFAIP3 and A20 as a Gateway Gene to Drug Induced Extrinsic Apoptosis."
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"Besides, TNFAIP3 overexpression relieved the spatial learning and memory, reduced the hot plate latency, as well as inhibited neuronal apoptosis in KA-treated mice."
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"However, it is unclear how the transfected TNFAIP3 triggers apoptosis in the lymphoma cells."
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"BIRC3 and TNFAIP3 negatively modulate apoptosis and necroptosis through the TNF signaling pathway (KEGG hsa04668)."
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"Conversely, TNFAIP3 is required to protect thymocytes or fibroblasts from TNF induced apoptosis, despite prolonged NF-kappaB activation."
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"Ginsenoside Rh2 Regulates the CFAP20DC-AS1/MicroRNA-3614-3p/BBX and TNFAIP3 Axis to Induce Apoptosis in Breast Cancer Cells."
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"In addition, exosomes generated from lipopolysaccharide (LPS)-activated microglia promote neuron apoptosis, which can reversed by the knockdown of TNF inducible protein 3 (TNFAIP3) [XREF_BIBR]."
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"Knockout of TNFAIP3 in CNE1 and CNE2 cells also significantly decreased the percentage of apoptosis after irradiation."
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"TNFAIP3 induced apoptosis and cell growth arrest, indicating a tumor suppressor role ( Compagno et al., 2009 )."
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