IndraLab

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TNFAIP3 activates apoptotic process. 24 / 25
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"Ginsenoside Rh2 Regulates the CFAP20DC-AS1/MicroRNA-3614-3p/BBX and TNFAIP3 Axis to Induce Apoptosis in Breast Cancer Cells."
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"Moreover, TNFAIP3 induces cell growth arrest and apoptosis, accompanied by down-regulation of nuclear factor-kappa B (NF-kB) activation [XREF_BIBR, XREF_BIBR]."
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"In addition, exosomes generated from lipopolysaccharide (LPS)-activated microglia promote neuron apoptosis, which can reversed by the knockdown of TNF inducible protein 3 (TNFAIP3) [XREF_BIBR]."
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"Accordingly, overexpression of a miR-29b-refractory isoform of TNFAIP3 restored NF-kappaB and extrinsic apoptosis, confirming that TNFAIP3 is a functionally relevant target of miR-29b."
29081842
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"Like CYLD , A20 suppresses cell proliferation and promotes apoptosis as a negative regulator of the NF-kappaB pathway , and it is well known to play an important role in inflammation and immunity ( Dixit et al. 1990 ; Hoesel and Schmid 2013 ) ."
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"Various viruses develop different strategies to limit or utilize apoptosis for benefitting their replication and persistent infection (44, 45) , PDCoV has CircRNA TNFAIP3 and Deltacoronavirus Replication ® been reported to induce caspase-dependent apoptosis during replication (46) ."
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"Conversely, TNFAIP3 is required to protect thymocytes or fibroblasts from TNF induced apoptosis, despite prolonged NF-kappaB activation."
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"In addition, TNFAIP3 re-expression can inhibit proliferation, decrease expression of target genes in NF-kappaB signaling pathway, increase cytotoxicity and induce apoptosis in cells lacking TNFAIP3."
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"However, it is unclear how the transfected TNFAIP3 triggers apoptosis in the lymphoma cells."
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"The deletions or mutations of TNFAIP3 are found in about 30% of patients with diffuse large B-cell lymphoma, while reinforced TNFAIP3 induces apoptosis and cell growth arrest XREF_BIBR, suggesting TNFAIP3 is a tumor suppressor."
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"In KRAS (G12V)-transduced bronchial epithelial (BEAS-2B) cells, introduction of anti-miR-29b constructs increased the sensitivity to apoptosis by targeting TNFAIP3 and A20, a negative regulator of nuclear factor (NF)-kappaB signaling."
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"Results demonstrated that TNFAIP3 knockdown contributed to the proliferation, migration, invasion, and inflammation and suppressed the apoptosis in HAND2-AS1-overexpressed MH7A cells."
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"TNFAIP3 and A20 as a Gateway Gene to Drug Induced Extrinsic Apoptosis."
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"TNFAIP3 can increase apoptosis by inhibiting the expression of Bcl-2 transcription factor NF-kappaB ."
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"miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus related hepatocellular carcinoma."
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"TNFAIP3, that was found to be up-regulated by TRAIL in our study, is an inhibitor of the NFKB pathway [XREF_BIBR] and may thereby promote apoptosis but, on the other hand, it was shown to decrease TNF mediated apoptosis and necrosis [XREF_BIBR], leaving its specific influence unclear."
19077262
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"A20 Like CYLD , A20 suppresses cell proliferation and promotes apoptosis as a negative regulator of the NF-kappaB pathway , and it is well known to play an important role in inflammation and immunity ( Dixit et al. 1990 ; Hoesel and Schmid 2013 ) ."
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"Silencing of TNFAIP3 or RIP3T led to elevated proliferation and inhibited apoptosis in AR42J cells, accompanied by decreased inflammatory cytokine levels and ROS production."
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"Accordingly, overexpression of an miR-29b-refractory isoform of TNFAIP3 restored NF-kappaB and extrinsic apoptosis, confirming that TNFAIP3 is a functionally relevant target of miR-29b."
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"Functional reconstitution of TNFAIP3 in TNFAIP3-null DLBCL causes apoptosis and growth arrest, supporting a tumor suppressor role in DLBCL ."
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"TNFAIP3 protein as a zinc finger protein and ubiquitin shearing enzyme can suppress activated NF-kappaB signal pathway and induce apoptosis of TNF by activating ubiquitin ligase and ubiquitinase."
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"Besides, TNFAIP3 overexpression relieved the spatial learning and memory, reduced the hot plate latency, as well as inhibited neuronal apoptosis in KA-treated mice."
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"TNF-alpha-induced-protein 3 (encoded by TNFAIP3) and its interacting protein, TNFAIP3 interacting protein 1 (encoded by TNIP1), are both key regulators of the NFkappaB signaling pathway (XREF_FIG), and modulate cell activation, cytokine signaling and apoptosis."
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"Knockout of TNFAIP3 in CNE1 and CNE2 cells also significantly decreased the percentage of apoptosis after irradiation."
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