IndraLab

Statements

USP8 deubiquitinates STAM. 4 / 4
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"<span class="match term0">UBPY</span> function is essential for effective downregulation but is likely to be multifaceted, encompassing activity against both K63-linked and K48-linked polyubiquitin chains and including regulation of the stability of ESCRT-associated proteins such as <span class="match term1">STAM</span>, by reversing their ubiquitination."
16996268
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"In addition, we identified STAM and NFX1, which are known to be deubiquitylated by USP8 and USP9 respectively."
33417828
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"USP8 deubiquitinates STAM, preventing its degradation by the proteasome [XREF_BIBR], and Nrdp1, an E3 required for the lysosomal degradation of EGFR family members ErbB3 and ErbB4 [XREF_BIBR]."
23845989
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"USP8 modulates EGFR trafficking by regulating STAM de-ubiquitination on early endosomes 11."
26459808