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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

TXN bound to MAP3K5 inhibits MAP3K5. 3 / 3

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"Trx1 and 14-3-3 bind to ASK1 and inhibit ASK1 activity."

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"DFO- and Dp44mT induced JNK activation was found to be mediated by Trx oxidation following iron chelation, causing dissociation of the ASK1 and Trx complex that normally inhibits ASK1 kinase activity and subsequent ASK1 dependent apoptosis [XREF_BIBR, XREF_BIBR]."

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"Trx1 directly interact with ASK1, a pro apoptotic kinase, thereby inhibiting the kinase activity of ASK1 independently of cysteine modification."

22904041

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Statements

TXN bound to MAP3K5 inhibits MAP3K5. 3 / 3

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