IndraLab

Statements

PSMD14 inhibits UIMC1. 3 / 3
| 3
reach
"POH1, as a component of the proteasome, may directly degrade RAP80, which allows access of ubiquitin chains to another DUB, or POH1 could remove the ubiquitin chains, which triggers loss of RAP80."
24013561
reach
"One proposed model is that POH1 degrades RAP80 and the loss of RAP80 dependent protection of the ubiquitin chain promotes the removal of ubiquitin, leading to the removal of 53BP1 from the IRIF; however, the detailed molecular mechanism remains to be elucidated."
30831436
reach
"The detailed molecular mechanism remains to be elucidated, but one proposed model is that POH1 degrades RAP80 and the loss of RAP80 dependent protection of the ubiquitin chain promotes the removal of ubiquitin, leading to the removal of 53BP1 from the core of IRIF [XREF_BIBR]."
26983989