IndraLab

Statements

USP1 leads to the ubiquitination of PCNA. 11 / 11
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"In particular, ROS mediated regulation of USP1 and UAF1 activity would contribute to modulate the level of PCNA monoubiquitination in response to oxidative stress [XREF_BIBR, XREF_BIBR]."
23937906
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"In human cells, UV irradiation triggers autocleavage of the C-terminal region of USP1, followed by proteasomal degradation of cleaved USP1, which increases mono-ubiquitination of PCNA [57]."
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"Usp1 -/- bone marrow (BM) cells had increased monoubiquitination of Fancd2 and PCNA, as observed in Usp1 -/- MEFs (data not shown)."
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"This is in contrast to UV mediated DNA damage whereby USP1 is degraded to enhance PCNA monoubiquitination, suggesting that alternate mechanisms inhibit USP1 activity in a time dependent manner (XREF_FIG)."
23219552
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"Remarkably, depletion of OTUB1 restored a pharmacologically disabled DSB response, indicating that targeting the OTUB1-E2 interaction might be an attractive route for the development of agents that bo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21056014
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"Expression of a non degradable form of USP1 decreased the level of UV induced PCNA ubiquitination."
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"These results are consistent with that Spartan functions as an antagonist of PCNA deubiquitylation by USP1."
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"Deregulation of PCNA monoubiquitination caused by RAD18 or USP1 deficiency leads to impaired cellular survival against UVC damage [XREF_BIBR, XREF_BIBR]."
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"As expected, while knockdowns of Rad18 and Usp1 decreased and increased PCNA monoubiquitylation, respectively (see XREF_SUPPLEMENTARY), they did not affect the localization of PCNA (XREF_SUPPLEMENTARY)."
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"Another important example of the role played by DUBs in DNA repair relates to USP1, a DUB that modulates both FANCD2 and FANCI and PCNA ubiquitylation XREF_BIBR, XREF_BIBR."
21056014
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"USP1 ablation increases FANCD2 and PCNA monoubiquitination but unexpectedly results in DNA crosslinker sensitivity."
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