IndraLab

Statements

Modified PTEN decreases the amount of PTEN. 6 / 6
| 6
reach
"Immunohistochemistry for PTEN on the PTEN-mutant, MSI-H tumors showed 4/9 (44%) of exon 8 mutants lost expression of PTEN (XREF_FIG), where the two exon 7 mutants had only diminished PTEN expression."
20845481
reach
"Therefore, moderate changes of PTEN levels elicited by loss of PTEN ceRNA expression are likely to contribute to melanomagenesis in the context of a B-Raf V600E initiating mutation."
24072616
reach
"In addition, the protein level of PTEN was also elevated by GAS5 overexpression; however, the GAS5 induced increase in PTEN protein expression was suppressed markedly by miR-32-5p overexpression, suggesting that miR-32-5p negatively regulated the expression of PTEN and mediated the effect of GAS5 on PTEN expression."
29225772
reach
"PTEN expression was markedly decreased in diabetic kidneys while XST partly restored PTEN expression."
32051833
reach
"The results showed that loss of PTEN and upregulation of Akt in and treatment with HO-3867 significantly restored PTEN levels and caused downregulation of Akt."
23339168
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR PTEN expression has also been shown to be downregulated by TGFbeta1 in keratinocytes, XREF_BIBR and PTEN mRNA levels were also reduced in a model of TGFbeta1 overexpressing transgenic mice that develop pancreatic fibrosis."
18769113