IndraLab

Statements

PDPK1 phosphorylated on Y376 is active. 3 / 3
3 |
signor
"Src-dependent pdk1 tyr373/376 tyrosine phosphorylation. / optimal activation of pdk1 requires phosphorylation of tyr373/376"
20643654
signor
"We have described that upon ligand binding, igf-1r directly interacts with and phosphorylates pdk1 at tyr373/376"
20044479
signor
"Previous studies indicate that optimal activation of PDK1 requires phosphorylation of Tyr373/376, and growth factor receptor activation leads to PDK1 recruitment to the plasma membrane, followed by sequential phosphorylation of Tyr9 and then Tyr373/376"
20643654