IndraLab

Statements

ESR1 binds IGF1R and IRS1. 3 / 3
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"Because ectopic expression of ERα reversed the I3C down-regulation of IGF1R and IRS1 transcript expression, the I3C disruption of ERα interactions with the IGF1R and IRS1 promoters mediates the I3C-dependent loss of IGF1R and IRS1 gene expression, respectively."
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"3.4 I3C disrupts ERα protein interactions with IGF1R and IRS1 promoters."
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"Our results demonstrate that the I3C mediated down-regulation of ERα causes the loss of ERα binding to the human IGF1R and IRS1 gene promoters and ablation of estrogen dependent transcriptional induction of these two ERα target genes."
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