IndraLab

Statements

PKC inhibits KCNMA1. 20 / 20
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"PKC inhibits BK channel activity at least in part by counteracting PKA induced channel activation."
19342611
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"In addition to redox-mediated modification of BK-α, it has been shown that PKC-induced serine phosphorylation at 695 (S695) and 1151 (S1151) in the C-terminus of BK-α inhibits BK channel current density by 50%, and S1151 phosphorylation by PKC also abolishes BK-α activation by protein kinase A (PKA) and protein kinase G (PKG; Zhou et al., 2001, 2010)."
34744789
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"20-HETE activates PKC and PKC may mediate contraction by inhibiting BK channel activity in rat cerebral arteries, rabbit portal vein, canine basilar artery and rat tail artery."
23977428
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"PKC reduces BK channel activity in vascular smooth muscle cells [45], and PKC activity is decreased during pregnancy in ovine and porcine UtA [46,47]."
36012712
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"Our previous study showed that activation of PKC inhibited basal BK channel current density in uterine arteries XREF_BIBR."
25013368
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"In contrast, PKC decreases BK channel activity [125]."
36834817
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"PKC catalytic subunit (PKCsu, 0.1 units/ml) decreased BK channel activity to 0.04434 +/- 0.00752 and NaHS had no significant effect (Po = 0.04609 +/- 0.00869, n = 10, equal to 104.92 +/- 16.09%)."
25429270
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"Activation of PKC is reported to inhibit BK channel activity in VSM via the putative phosphorylation of Ser695 and Ser1151, and these modifications also appear to interfere with the stimulatory effects mediated by PKA and PKG."
25202279
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"Stimulation of protein kinase C activity with phorbol ester completely inhibits BK channel activity in GH 4 C 1 cells (Shipston and Armstrong, 1996)."
8938725
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"This idea is supported by our patch-clamp studies that PKC activation inhibits BK channel opening [XREF_BIBR], releasing that channel 's inhibitory effect on the L-type Ca 2+ channels, thus allowing increased Ca 2+ influx."
24063382
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"Phosphorylation of serine-695 by protein kinase C blocks BK channel activity, and phosphorylation of serine-1151 by protein kinase C enhances the BK channel response to activation by guanosine 3′,5′-monophosphate-dependent protein kinase [31]."
37223477
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"BK channel inhibition by PKC, however, was effectively established when the palmitoylation-mediated membrane-anchor of the STREX insert was removed by either pharmacological inhibition of palmitoyl transferases or site-directed mutagenesis."
22843729
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"Activation of protein kinase C inhibits the BK channel in uterine arteries [233,262]."
36674858
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"Thus, vasoconstriction induced by α-adrenergic ligands and thromboxane may involve PKC-mediated inhibition of the BK channel in this vessel [263,264]."
36674858
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"Activation of PKC inhibits BK channel activity and increases myogenic tone in the uterine arteries of pregnant sheep [233]."
36674858
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"PKC is known to cause inhibition of BK channel activity from GH cells."
25429270
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"BK channel inhibition by PKC, however, was effectively established when the palmitoylation mediated membrane-anchor of the STREX insert was removed by either pharmacological inhibition of palmitoyl transferases or site directed mutagenesis."
22843729
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"In support of this suggestion are demonstrations of protein kinase C inhibition of Slo1 K + channel inhibition in vascular smooth muscle, although protein kinase C activation of Slo1 K + channel has also been reported."
29755343
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"Although PKC dependent inhibition of MaxiK channels is well known, its role as an inhibitory pathway induced by muscarinic M2 receptors was only addressed recently."
24077696
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"BK channels have been reported to be PIP 2 dependent ( xref , xref ); however, a link between PKC-dependent BK channel inhibition and PIP 2 has not been reported."
35588786