IndraLab

Statements

PKC inhibits KCNMA1. 13 / 13
| 12 1
reach
"In addition to redox-mediated modification of BK-α, it has been shown that PKC-induced serine phosphorylation at 695 (S695) and 1151 (S1151) in the C-terminus of BK-α inhibits BK channel current density by 50%, and S1151 phosphorylation by PKC also abolishes BK-α activation by protein kinase A (PKA) and protein kinase G (PKG; Zhou et al., 2001, 2010)."
34744789
reach
"20-HETE activates PKC and PKC may mediate contraction by inhibiting BK channel activity in rat cerebral arteries, rabbit portal vein, canine basilar artery and rat tail artery."
23977428
reach
"PKC catalytic subunit (PKCsu, 0.1 units/ml) decreased BK channel activity to 0.04434 +/- 0.00752 and NaHS had no significant effect (Po = 0.04609 +/- 0.00869, n = 10, equal to 104.92 +/- 16.09%)."
25429270
reach
"PKC inhibits BK channel activity at least in part by counteracting PKA induced channel activation."
19342611
reach
"Our previous study showed that activation of PKC inhibited basal BK channel current density in uterine arteries XREF_BIBR."
25013368
reach
"Although PKC dependent inhibition of MaxiK channels is well known, its role as an inhibitory pathway induced by muscarinic M2 receptors was only addressed recently."
24077696
reach
"Activation of PKC is reported to inhibit BK channel activity in VSM via the putative phosphorylation of Ser695 and Ser1151, and these modifications also appear to interfere with the stimulatory effects mediated by PKA and PKG."
25202279
reach
"BK channel inhibition by PKC, however, was effectively established when the palmitoylation mediated membrane-anchor of the STREX insert was removed by either pharmacological inhibition of palmitoyl transferases or site directed mutagenesis."
22843729
reach
"This idea is supported by our patch-clamp studies that PKC activation inhibits BK channel opening [XREF_BIBR], releasing that channel 's inhibitory effect on the L-type Ca 2+ channels, thus allowing increased Ca 2+ influx."
24063382
sparser
"BK channel inhibition by PKC, however, was effectively established when the palmitoylation-mediated membrane-anchor of the STREX insert was removed by either pharmacological inhibition of palmitoyl transferases or site-directed mutagenesis."
22843729
reach
"PKC is known to cause inhibition of BK channel activity from GH cells."
25429270
reach
"In support of this suggestion are demonstrations of protein kinase C inhibition of Slo1 K + channel inhibition in vascular smooth muscle, although protein kinase C activation of Slo1 K + channel has also been reported."
29755343
reach
"Stimulation of protein kinase C activity with phorbol ester completely inhibits BK channel activity in GH 4 C 1 cells (Shipston and Armstrong, 1996)."
8938725