IndraLab

Statements

INS leads to the phosphorylation of JAK2. 13 / 13
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"In carp hepatocytes, insulin did not trigger JAK 2 and STAT 5 phosphorylation but the elevation in IGF-I and -II mRNA levels induced by insulin were blocked by inhibiting JAK 2 and STAT 5 (by AG490 and NICO, respectively)."
29977227
sparser
"To investigate whether insulin could induce JAK2 tyrosine phosphorylation in the rat hypothalamus, as described in other tissues and cultured cells , we infused insulin i."
11445068
sparser
"The acute treatment with epinephrine showed no difference in insulin-induced JAK2 tyrosine phosphorylation or JAK2/STAT1 and JAK2/SHP2 association in comparison with the control."
11032244
sparser
"In carp hepatocytes, insulin did not trigger JAK 2 and STAT 5 phosphorylation but the elevation in IGF-I and -II mRNA levels induced by insulin were blocked by inhibiting JAK 2 and STAT 5 (by AG490 and NICO, respectively)."
29977227
sparser
"That is, insulin induces JAK2 tyrosine phosphorylation, and also increases STAT3 phosphorylation and activation in the presence of leptin [37] ."
12535710
bel
"1) insulin and IGF-1 lead to phosphorylation and activation of JAK-1 and JAK-2 in intact cells"
9492017
sparser
"Saad et al. reported that insulin induces tyrosine phosphorylation of JAK2 ()."
12890573
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"Akt, FoxO1, JAK2, and STAT3 phosphorylation in response to ICV insulin or leptin, respectively, were evaluated as described."
22966070
sparser
"In agreement with this hypothesis, the time-course of insulin-induced JAK2 tyrosine phosphorylation preceded that of OBR phosphorylation."
11445068
sparser
"In fasting and dexamethasone-treated rats, therefore, insulin-induced JAK2 tyrosine phosphorylation decreases, and the JAK2 protein expression is differentially regulated such that the insulin-induced JAK2 association with SHP2 and STAT1 shows opposite interactions with the kinase."
11032244
reach
"Taking our data together, we conclude that : 1) insulin and IGF-1 lead to phosphorylation and activation of JAK-1 and JAK-2 in intact cells; 2) phosphorylation of IRS-I by JAK-1 seems to occur on sites different from those phosphorylated by the insulin receptor; 3) JAK-1 interacts directly with phosphorylated insulin and IGF-1 receptors; and 4) the JH7-JH6 and JH1 domains of JAK-1 are responsible for the interaction with insulin and IGF-1 receptors."
9492017
sparser
"Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat."
8703019
sparser
"Insulin induced JAK2 tyrosine phosphorylation, leptin receptor phosphorylation which, in the presence of leptin, augmented the interaction between STAT3 and this receptor."
11445068