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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

AKT phosphorylates GSK3 at position 21. 2 / 2

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"DCT induced PI3K and Akt activation resulted in downstream phosphorylation of GSK-3 (Ser (21/9)) and BAD (Ser (136)), and nuclear translocation (activation) of NF-kappaB, thereby confirming that DCT induced activation of PI3K and Akt signaling regulates both proproliferative and prosurvival signals."

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"Akt phosphorylates GSK-3 at Serine 21 and Serine 9 in two different isoforms GSK-3 and GSK-3 respectively and inhibits its activity [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...