IndraLab

Statements

CHEK2 phosphorylates TP53 on T18. 11 / 11
1 4 | 3 3
reach
"In contrast to Cdc25A, p53 is phosphorylated not only by Chk1 and Chk2 (on Thr18, Ser20, and possibly other residues) but also directly by the upstream checkpoint kinases ATM and ATR, particularly, on[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15279786
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10656682
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10710310
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
17339337
sparser
"ATM also activates CHK2, a serine threonine kinase, which phosphorylates p53 at threonine 18 and serine 20."
22778557
biopax:phosphositeplus
No evidence text available
reach
"The N-terminal activation domain of p53 does not contain the classical Chk1 and Chk2 consensus target sequence found in other substrates such as the Cdc25 phosphatases, and the physiological tetrameri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15279786
reach
"CHK2 also phosphorylates P53 Thr18 and Ser20 to promote p21 accumulation and to maintain G2/M arrest."
32518522
sparser
"ATM-activated Chk2 kinase also phosphorylates p53 at the threonine-18 and serine-20 residues [ xref , xref ]."
34440406
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10673501
sparser
"CHK2 also phosphorylates P53 Thr18 and Ser20 to promote p21 accumulation and to maintain G2/M arrest."
32518522