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Capzimin bound to PSMD14 activates PSMD14. 1 / 1

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"They subsequently improved the potency of 8TQ by an approach based on structure–activity relationship and identified that capzimin, a molecule that binds the catalytic site of POH1 (Fig. 3), has greatly enhanced selectivity for POH1 over other JAMM metalloenzymes and sevenfold more potency towards POH1 (IC = 0.34 mM) [6]."

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Capzimin bound to PSMD14 activates PSMD14. 1 / 1

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