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Statements

IL6 leads to the phosphorylation of STAT3 on S727. 34 / 34
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"However, EB did not inhibit the IL-6-induced Ser727 phosphorylation of STAT3 ( xref ), suggesting that EB inhibited STAT3 activation through inhibiting Tyr705 phosphorylation of STAT3."
26010889
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"Transfection of cells with dominant negative STAT3 (S727A) mutant did not affect basal STAT3 (S727) phosphorylation but the STAT3 (S727) phosphorylation and translocation in response to IL-6 was lost (XREF_FIG)."
25740948
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"Recently, we have demonstrated that IL-6 induced STAT3 Ser727 phosphorylation and that transactivation requires activation of the GTPase Rac-1 [25] ."
11322950
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"Vav, Rac1, MEKK1, and SEK but not JNK or ERK1 have been implicated as components of a pathway that leads to serine 727 phosphorylation of Stat3 by IL6 in HepG2 cells [65] ."
11728826
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"Furthermore, HMC was also able to suppress the IL-6 induced phosphorylation of STAT-3 at serine 727 and tyrosine 705 residues in K-562 cells ( Fig. 6 D)."
26291658
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"Pretreatment of ECs with Mag dose dependently inhibited IL-6-induced Tyr705 and Ser727 phosphorylation in STAT3 without affecting the phosphorylation of JAK1, JAK2, and ERK1/2."
16520748
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"Studies have shown that IL-6 induces STAT3 phosphorylation on both Tyr705 and Ser727 [ xref , xref ]."
27074565
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"Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells."
21538419
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"Similar results were subsequently reported for IL-6-induced S727 phosphorylation of STAT3 ( xref )."
23352233
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"IL-6 induces STAT3 phosphorylation at Tyr-705 and Ser-727 through IL-6 receptors and JAK to activate STAT3 signalling in HCC cells."
26061710
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"Furthermore, IL-6 has been reported to induce Ser 727 phosphorylation of STAT3 through an ERK independent pathway (Chung et al., 1997)."
17081797
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"An earlier in vitro study had suggested that IFN-γ-induced phosphorylation of serine 727 (S727) in STAT1-TAD occurs only on promoter-bound STAT1 [ xref ], which is similar to IL-6-induced S727-phosphorylation of STAT3 [ xref ]."
29662014
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"Vav, Rac1, MEKK1, and SEK but not JNK or ERK1 have been implicated as components of a pathway that leads to serine 727 phosphorylation of Stat3 by IL6 in HepG2 cells [65]."
11728826
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"In addition, intracisternal injection of IL-6 by itself significantly increased phosphorylation of STAT3 at Tyr705 and Ser727."
16413512
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"An involvement of p38 mitogen-activated protein kinase (MAPK) in the IL-6-induced phosphorylation on serine 727 of Stat3 in hepatocytes was recently proposed ."
11056211
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"In the presence of 50 muM Stattic, a non peptide small molecule inhibitor of STAT3 SH2 domain function, STAT3 (S727) phosphorylation induced by 20 ng/ml IL-6 was inhibited 3.5 +/- 0.18 fold, STAT3 (Y705) phosphorylation increased 2.4 +/- 0.12 fold and SOC3 levels increased 3.2 +/- 0.16 fold (XREF_FIG)."
25740948
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"IL-6 induces STAT3 phosphorylation at Tyr 705 and Ser 727 through IL-6 receptors and JAK to activate STAT3 signalling in HCC cells."
26061710
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"Con-stitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6."
16036105
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"However, IL-6 receptor activation induces the phosphorylation of both the Y705 and S727 residues of STAT3, and S727 phosphorylation is required to achieve maximal STAT3 transcriptional activity."
29082496
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"In this process, serine727 phosphorylation of STAT-3 by IL-6-IL-6R plays a crucial role xref ."
28128332
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"Similarly to GW501516, U0126 prevented the reduction in insulin stimulated Akt phosphorylation (XREF_FIG) and glucose-uptake (XREF_FIG) and prevented the increase in STAT3 phosphorylation on Ser 727 (XREF_FIG) caused by IL-6."
21617181
bel
"Moreover, STAT3 phosphorylation (Tyr705 and Ser727) could be induced by the addition of IL-6"
16278387
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"Importantly, PD 98059 markedly reduced IL-6-induced STAT3 S727 phosphorylation and significantly inhibited STAT3 transcription as measured by M67 SIE luciferase activity 3 hours or 6 hours following IL-6 treatment ( xref )."
21619877
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"As expected, phosphorylation of STAT3 at both Ser727 and Tyr705 was induced by IL6 treatment."
24687132
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"IL-6 increases STAT3 activation by phosphorylating STAT3 on tyrosine 705 and/or serine 727 in a broad range of human malignancies at the probability of 50% to 90% (Jiang et al., 2011; Wang et al., 201[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26101800
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"IL-6 induced phosphorylation of STAT3 at both Tyr705 and Ser727 (Fig. xref and xref )."
26417930
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"An earlier in vitro study had suggested that IFN-γ-induced phosphorylation of serine 727 (S727) in STAT1-TAD occurs only on promoter-bound STAT1 [65], which is similar to IL-6-induced S727-phosphorylation of STAT3 [66]."
29662014
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"Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6."
10845908
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"Both autocrine and paracrine IL-6 can lead to constitutive phosphorylation of STAT3 at Tyr705 and Ser727 residues; IL-6 from paracrine sources (such as cancer-associated myeloid cells or fibroblasts) could induce autocrine IL-6 production and STAT3 phosphorylation in tumor cells (9)."
33313091
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"IL-6-induced STAT3 serine 727 phosphorylation is discussed to be a fine tuner of IL-6-induced JAK/STAT signalling."
30675525
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"In HCC cells, interleukin 6 stimulates the phosphorylation of STAT3 both at serine 727 and at tyrosine 705 positions."
17237271
bel
"Only phosphorylation of STAT3 at ser 727 site paralleled the IL-6 stimulation, and JSI-124, a specific JAK-STAT3 pathway blocker, deterred the invasion and migration promotive effect of IL-6, indicating that the JAK/STAT3 pathway mediates signal transduction."
20361349
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"As shown in XREF_FIG, STAT3 Ser727 phosphorylation induced by IL6 and TGFbeta was significantly attenuated in IRAK-1 -/- cells."
19380824
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"IL-6 (10 mug/ml) induced STAT3 (S727) phosphorylation and nuclear translocation (XREF_FIG)."
25740948