IndraLab

Statements

AGT activates KCNMA1. 6 / 6
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"Using patch clamp techniques and molecular biological approaches, we found that BK channels, Ang II type 1 receptor, G (alphaq/11) (G protein q/11 alpha subunit), nonphagocytic NAD (P) H oxidases (NOX-1), and c-Src kinases (c-Src) were colocalized in the caveolae of rat arterial smooth muscle cells and the integrity of caveolae in smooth muscle cells was critical for Ang II mediated BK channel regulation."
20167931
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"Under some specific conditions, Ang II can also activate the BK channel, but the underlying mechanism remains unknown."
31008478
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"However, the molecular mechanisms underlying Ang II mediated BK channel modulation, especially in diabetes mellitus, have not been thoroughly examined."
20167931
sparser
"Under some specific conditions, Ang II can also activate the BK channel, but the underlying mechanism remains unknown."
31008478
reach
"Experimental results of Leo et al. showed that the constriction to iberiotoxin (10 nM, IBTX) and dilation to NS-1619 (BK channel specific activator) (10 muM) of Ang II (100 nM, 8 h)-treated arteries were less than those in control untreated arteries, suggesting that Ang II stimulates BK channel internalization and degradation, leading to the construction of cerebral arteries."
28955251
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"We found that BK channels, AT 1 R, G alphaq/11, non phagocytic NAD (P) H oxidases (NOX-1) and c-Src kinases (c-Src) were co-localized in the caveolae of rat arterial smooth muscle cells (SMC) and the integrity of caveolae in SMC was critical for Ang II mediated BK channel regulation."
20167931