IndraLab

Statements


Modified USP1 leads to the ubiquitination of PCNA. 3 / 3
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"Low levels of USP1 enable robust UV induced PCNA monoubiquitination during G1, which is likely to allow the recruitment of TLS polymerases to UV lesions."

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"The high levels of USP1 during unperturbed S-phase allow any unwarranted ubiquitination of PCNA that may occur during normal DNA replication to be counteracted."

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"Low levels of USP1 enable robust UV-induced PCNA mono-ubiquitylation during G1, which is likely to allow recruitment of TLS polymerases to UV lesions [76]."