IndraLab

Statements

USP18 inhibits JAK1. 5 / 7
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"USP18 competes with JAK1 for IFNAR2 receptor binding, reducing JAK1 and STAT activation (15, 16)."
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"USP18 inhibits type I interferon signaling by preventing Janus-associated kinase 1 (JAK1) from binding to the type I interferon receptor."
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"One group has proposed that USP18 attenuates IFN alpha signaling regardless of the isopeptidase activity of the protein by competitively displacing Jak1 from its interaction with IFNAR2 XREF_BIBR."
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"USP18 has been shown to suppress the Jak-STAT pathway through specific binding to IFNAR2 and restricting the access of the Jak1 kinase to its docking site at the receptor ( Fig. 2 ) [52] ."
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"Postactivation silencing of IFNAR signaling is achieved quickly after IFN exposure and is mediated by at least two proteins that are ISGs themselves and therefore accumulate in response to IFN: Suppressor of cytokine signaling 1 (SOCS1) binds and inhibits TYK2, whereas USP18 (UBP43) occupies IFNAR2 and hence blocks JAK1 activation (83, 84)."
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