IndraLab

Statements

USP18 inhibits JAK1. 4 / 6
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"USP18 interacts with IFNAR2 to prevent JAK1 from interacting with IFNAR2 , and thus , USP18 suppresses signal transmission from IFN-alpha binding [ 47 , 48 ] ."
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"Postactivation silencing of IFNAR signaling is achieved quickly after IFN exposure and is mediated by at least two proteins that are ISGs themselves and therefore accumulate in response to IFN: Suppressor of cytokine signaling 1 (SOCS1) binds and inhibits TYK2, whereas USP18 (UBP43) occupies IFNAR2 and hence blocks JAK1 activation (83, 84)."
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"USP18 interacts with IFNAR2 to prevent JAK1 from interacting with IFNAR2, and thus, USP18 suppresses signal transmission from IFN-α binding [47,48]."
32276399
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"One group has proposed that USP18 attenuates IFN alpha signaling regardless of the isopeptidase activity of the protein by competitively displacing Jak1 from its interaction with IFNAR2 XREF_BIBR."
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