IndraLab

Statements

PSMD14 inhibits autophagy. 5 / 5
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"PSMD14/POH1 deubiquitinase prevents IRF3 autophagy by cleaving its K27-linked polyubiquitin chain in lysine 313 to promote IRF3-mediated type I IFN activation (161)."
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"Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC."
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"In this regard, it has been demonstrated that PSMD14 loss of function inhibits autophagy by blocking Golgi-to-ER retrograde transport, a phenotype that is not observed with the inhibition of the CP in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, PSMD14 can promote stability of LRPPRC to disrupt autophagy in accelerating ovarian tumor growth and invasion [ 52 ]."
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"PSMD14 inhibits autophagy and thus influences the progression of ovarian cancer through the LRPPRC/Beclin1-Bcl-2/SQSTM1 signaling pathway (20)."
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