IndraLab

Statements

Reactive oxygen species inhibits NFKBIA. 4 / 4
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"We observed that TC-HW-mediated NF-kappaB activation is followed by p65 nuclear accumulation through ROS dependent degradation of IkappaB-alpha."
29554905
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"These data collectively indicated that this ROS mediated IkappaBalpha independent regulation on NF-kappaB activation may not be restricted by the specificity of stimulators or ROS scavengers."
24725826
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"The combination of ROS quenching by the free radical scavenger Tempol and of Bcl10 silencing by siRNA completely inhibited the CGN induced increases in nuclear NFkappaB (p65), phospho-IkappaBalpha, and secretion of IL-8."
18452717
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"NF-kappaB translocation and transcriptional activity are dependent the degradation of IkappaB, which prevents NF-kappaB nuclear entry by covering the nuclear localization sequence XREF_BIBR, Therefore, we assessed the status of IkappaBalpha and found that IkappaBalpha degradation was dramatically induced by ROS accumulation following PQ treatment."
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