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Reperfusion Injury increases the amount of USP18. 2 / 2
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"For example, ischemic reperfusion injury upregulates USP18 expression in the liver and induces an IFN-α refractory state."

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"In vivo, hepatic inflammatory stress (ischemia/reperfusion injury) led to increased hepatic USP18 gene expression that was associated with poor control of LCMV infection."