IndraLab

Statements

Mutated TP53 increases the amount of mutated TP53. 5 / 5
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"Residual wild-type p53 in heterozygous mutant p53 tumor systems is capable of partial suppression of HSF1 activity, thereby necessitating loss of p53 heterozygosity in order to fully stabilize mutant p53 expression ."
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"As compared with EV transfected cells, let-7i promoter activity was significantly reduced by exogenous mutant p53 (XREF_FIG), suggesting that mutant p53 represses let-7i transcription."
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"Several studies documented the importance of either wild-type or mutant p53 alleles in leading to increased expression of p53 protein increased expression of both wild-type and mutant p53 protein."
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"Despite the partial or complete loss of sequence specific DNA binding, mutant p53 proteins can induce or repress transcription of mutant p53 specific target genes and various mutant p53 proteins can bind to oligonucleotides mimicking non B DNA structures [XREF_BIBR]."
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"Together, these observations support a role for germline p53 pathway SNPs not only in modulating risk of disease and tumor biology in wtTP53 cancers but also in TP53 mutant cancers, wherein alleles that increase mutant p53 levels would also increase its procancer activities."
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