IndraLab

Statements

USP25 inhibits STING1. 4 / 4
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"The deubiquitinase USP21 can negatively regulate STING activity by removing K27- and K63 linked ubiquitin chains of STING [XREF_BIBR]."
33670221
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"Hence, at late stages of viral infection, p38-mediated phosphorylation of USP21 (Ubiquitin Specific Peptidase 21), a deubiquitinating enzyme, inhibits STING."
33922633
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"Our data showed that phosphorylation of USP21 by p38 promotes its binding to STING and inactivates STING in response to HSV-1 infection."
28254948
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"Our data showed that overexpression of USP21 blocked translocation of STING from ER to a perinuclear microsome upon HSV-1 infection (XREF_FIG)."
28254948