IndraLab

Statements

RELN activates HCN1. 4 / 4
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"Loss of Reelin or Dab1 Drastically Reduces HCN1 Localization in the Distal Dendrites."
25201528
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"Although Reln signaling specifies this gradient [58], 17β-estradiol, which stimulates Reln expression, promoted the enrichment of HCN1 in the distal dendritic compartment of CA1 neurons without the intervention of Reln [59]."
31805691
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"We therefore reasoned that the GST-RAP-induced inhibition of Reelin signaling was either not sufficient to suppress the E2 induced increase of HCN1 in distal CA1 or, more generally, that Reelin is not required for the distal HCN1 enrichment in our experimental setting."
30406178
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"Thus, specific blockade of Reelin signaling blocks the enrichment of HCN1 and GIRK1 in the distal dendritic compartment, with little effect on protein levels in the soma and proximal dendrites."
25201528