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USP14 increases the amount of endoplasmic reticulum. 2 / 2
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"Our results further demonstrate that USP14 depletion decreases the expression of ERα-regulated genes in EC-derived cell lines."

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"To investigate whether the downregulation of ERα was due to the inhibition of USP14 and UCHL5 in combination, we observed that IU1, an inhibitor of USP14 suppressed a little ERα expression in protein (Supplementary Fig. S4a–c)."