IndraLab

Statements

RAS binds KRAS and RAF1. 5 / 5
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"Structural superposition of WT KRAS-RBDCRD with all three mutant structures shows similar interaction interfaces, suggesting that the two RAS-binding domains of RAF1 bind to oncogenic KRAS mutants similarly to WT KRAS (Fig.  xref )."
33608534
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"In fact, the interaction between these two proteins was first described in a Y2H screening and largely occurs through interaction of the N-terminal (aa 56–131) Ras-binding domain (RBD) of CRAF and the effector-binding domain of KRAS (aa 32–40) in a GTP-dependent manner ( xref , xref )."
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"Subsequent interaction of the RAF1 RAS binding domain with KRAS does not significantly change G-domain configurations on the membrane but affects their relative populations."
32913056
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"KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation."
33608534
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"Analysis of the canonical RAS-RAF-MEK-ERK signaling cascade ( xref ) after reversion of the mesenchymal H157 and H1155 KRAS mutant cells to an epithelial state through induced, stable, or transient expression of miR-200, showed an increase in KRAS binding to the RAS binding domain (RBD) of RAF1 (CRAF), followed by activation of MAPK signaling ( xref and xref , xref )."
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