IndraLab

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Acetylated TP53 activates apoptotic process. 15 / 15
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"In the absence of SIRT1 activity cells became more sensitive to stress conditions apoptosis can be triggered by transcriptional activities of increased expression levels of acetylated p53 and its targ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The association between these two proteins was acetylation independent, but acetylation of p53 could prevent and disrupt the Ku70 and BAX complex and enhance apoptosis."
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"Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53 dependent modulation of mitochondrial membrane potential and apoptosis."
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"Consequently, the acetylated p53 caused cell cycle arrest and apoptosis induction [4] ."
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"Highly acetylated p53 will cause apoptosis in cancer cells [ 48 , 49 ]."
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"Excessive accumulation of reactive oxygen species (ROS) can stimulate acetylated p53 to promote cell senescence and apoptosis [83,84]."
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"Low Dose Valproic Acid Enhances Radiosensitivity of Prostate Cancer through Acetylated p53 Dependent Modulation of Mitochondrial Membrane Potential and Apoptosis."
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"To further investigate the physiological significance of SET and TAF-Ibeta in acetylated p53 mediated apoptosis, we used the developing Drosophila eye as an in vivo model system."
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"In response to DNA damage, acetylation of p53 is stimulated and acetylated p53 enhances its ability to induce cell-cycle arrest, apoptosis, and DNA damage repair (Smith and La Thangue, 2005)."
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"This acetylation process is GSK-3-dependent, as activation of Tip60 requires GSK3-mediated phosphorylation and the resulting acetylated p53 can induce PUMA to initiate apoptosis [73]."
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"AMPK phosphorylates SIRT1 at Thr344 and thus inhibits its deacetylase activity and substrate binding capacity and consequently maintains acetylated p53 levels, which promote apoptosis."
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"Moreover, because p53 acetylation is regarded as crucial for its transcription independent proapoptotic functions, p53 acetylation may prevent or disrupt the formation of the Ku70 and BAX complex and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In response to apoptotic stimuli, p53 and FOXO3 are acetylated and activated to promote apoptosis, while Sirt1 deacetylates acetylated p53 and FOXO and prevents apoptosis [29] ."
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"Subsequently, the acetylated p53 promotes apoptosis of cancer cells by transcriptionally activating several pro apoptotic genes such as Noxa and Puma in response to DNA damaging drugs such as DOX [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"SIRT1 can alter the cellular apoptosis process by rendering deacetylation of the acetylated p53, where acetylated p53 can promote oxidative-stress-induced apoptosis [79–81] ."
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