IndraLab

Statements

Acetylated TP53 activates apoptotic process. 7 / 7
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"The association between these two proteins was acetylation independent, but acetylation of p53 could prevent and disrupt the Ku70 and BAX complex and enhance apoptosis."
19265193
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"To further investigate the physiological significance of SET and TAF-Ibeta in acetylated p53 mediated apoptosis, we used the developing Drosophila eye as an in vivo model system."
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"In response to DNA damage, acetylation of p53 is stimulated and acetylated p53 enhances its ability to induce cell-cycle arrest, apoptosis, and DNA damage repair (Smith and La Thangue, 2005)."
20160719
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"Moreover, because p53 acetylation is regarded as crucial for its transcription independent proapoptotic functions, p53 acetylation may prevent or disrupt the formation of the Ku70 and BAX complex and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"AMPK phosphorylates SIRT1 at Thr344 and thus inhibits its deacetylase activity and substrate binding capacity and consequently maintains acetylated p53 levels, which promote apoptosis."
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"Low Dose Valproic Acid Enhances Radiosensitivity of Prostate Cancer through Acetylated p53 Dependent Modulation of Mitochondrial Membrane Potential and Apoptosis."
21303901
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"Subsequently, the acetylated p53 promotes apoptosis of cancer cells by transcriptionally activating several pro apoptotic genes such as Noxa and Puma in response to DNA damaging drugs such as DOX [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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