IndraLab

Statements

CDK4 binds CDKN1B and CCND1. 27 / 28
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"Moreover, co-treatment with IGF-I and FGF-2 increased cyclin D1 association of cdk4 and p27(Kip1) significantly compared to FGF-2 treated cells ( P ≤ 0.02)."
15033176
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"Altered phosphorylation of p27 in the resistant 184A1L5(R) cells may favor the binding of p27 to cyclin D1-cdk4 and prevent its accumulation in cyclin E1-cdk2 in response to TGF-beta."
11940657
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"Together, these data indicate that the interaction of p21 with cyclin D1, CDK4, and CDK2, and the interaction of p27 with cyclin D1 and CDK4, is not impaired in Fah/p53 -/- mice."
33484913
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"Specifically, p21 Waf1/Cip1 binds to cyclin D1-CDK4 complex (at high stoichiometric ratios), and p27 Kip1 binds to cyclin D1 or cyclin D1-CDK4 complex, inhibiting their activity."
25609198
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"Similarly, IP with an anti-p27 antibody showed an interaction of p27 with cyclin D1 and CDK4 in both Fah/p53 -/- and in Fah -/- mice."
33484913
sparser
"While p27KD reduces the concentration of the assembled p27-cyclin D1-cdk4 ternary complex, removing PD’s target, it would also release cdk2, which has been shown competent to drive proliferation in the absence of cdk4 ( xref )."
29330290
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"However, Src treatment led to tyrosine phosphorylation of p27 and catalytic activation of assembled cyclin D1-Cdk4-p27 complexes."
18710949
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"Immunoprecipitation experiments revealed that p27Kip1 preferentially associated with CdK4 in Ang II-treated LLC-PK1 cells and that the activity of this kinase was inhibited after Ang II-treatment, an effect that may be generated by increased p27Kip1 binding to cyclin D1-CdK4 complexes."
8943498
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"In mouse fibroblasts, p27 is associated predominantly with cyclin D1-Cdk4."
8033213
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"The predicted protein structure for CDK4-007 transcript is derived from the p27/CDK4/CCND1 complex [24], while the predicted protein structure for CDK4-001 transcript is derived from the CDK4/CCND3 complex [32]."
39004679
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"In proliferating 184A1L5(R) cells, more p27 was associated with cyclin D1-cdk4 complexes than in 184(S)."
11940657
reach
"Therefore, it can be inferred that the higher occurrence of the CDK4-SE2 alternative splicing event in CRC leads to an increased production of the CDK4-007 transcript and subsequent formation of the p27/CDK4/CCND1 complex."
39004679
reach
"Consequently, in our data analysis, we specifically focus on an exon 2 skipping event in CDK4.This leads to the production of a truncated CDK4 protein that coexists within the p27-CDK4-CCND1 complex."
39004679
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"The results of the complex association analyses demonstrated that association of cdk4 and p27(Kip1) with cyclin D1 directly correlated with cyclin D1 induction."
15033176
sparser
"While TGF-beta inhibited the formation of cyclin D1-cdk4-p27 complexes in 184(S) cells, it did not inhibit the assembly of cyclin D1-cdk4-p27 complexes in the resistant 184A1L5(R) cells."
11940657
sparser
"p16 dissociated cyclin D1-Cdk4 complexes with the release of bound p27(KIP1), while Cdk4(N158) formed complexes with cyclin D1 and p27."
9710613
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"P27, a key cell cycle protein kinase inhibitor, formed a complex with CCND1 and CDK4 that prevents CDK4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein and blocks the cell-cycle G1/S transition."
24359578
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"P27 binds to the Cdk4-cyclin D1 complex preventing phosphorylation of the retinoblastoma (Rb) protein and release of the elongation factor E2F. This prevents the transcription of many of the proteins required for the cell to transit the 'S' phase."
15207007
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"The proteins p27, CDK4, and cyclin D1 are associated with the cell cycle and proliferation [ xref – xref ]."
32206038
sparser
"In conclusion, our results suggest that NBL1 could inhibit PDGF-BB-induced human PASMC proliferation, and the underlying mechanism is associated with the decreased cyclin D1–CDK4 activity and up-regulated p27 by decreasing the phosphorylation of p27 via blockade of PDGFRβ-p38MAPK signal cascade."
27474499
sparser
"During this process, p27 Kip1 tightly binds to the cyclin D1–CDK4 complex and induces cell cycle arrest xref , xref ."
30770784
sparser
"Nevertheless, this does not explain that the abundant p27 in G 0 cells is unable to assemble ectopically overexpressed cyclin D1 into CDK4 complexes in serum-starved fibroblasts [12] and, conversel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14597415
sparser
"Interestingly, such phenomenon was not observed in the PDAC model (1222), further confirming that only a very small fraction of cyclin D1 and CDK4 could form complex with p27 due to its low baseline expression ( xref )."
33323381
reach
"However, given the biased formation of the complex containing the truncated CDK4 in CRC, it may be feasible to achieve targeted therapy exclusively against CRC by designing inhibitors that specifically target the p27-CDK4-CCND1 complex in CRC or by identifying upstream splicing factors that regulate the splicing of CDK4 exon 2."
39004679
sparser
"The interaction between p27 KIP1 , cyclin D1, and CDK4 was enhanced by galectin-3 depletion."
24971481
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"In addition, the binding of the CDK2 inhibitor p27 to CDK2 was decreased in AMBRA1 -knockout cells and cells expressing cyclin D1(T286A), and at the same time p27 was more abundantly bound to cyclin D1 and CDK4 ( xref , xref , xref )."
33854239
sparser
"The interaction between p27 KIP1 , cyclin D1, and CDK4 was also decreased by galectin-3 overexpression."
24971481