IndraLab

Statements

CCND1 binds CDK4 and CDKN1B. 25 / 25
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"While TGF-beta inhibited the formation of cyclin D1-cdk4-p27 complexes in 184(S) cells, it did not inhibit the assembly of cyclin D1-cdk4-p27 complexes in the resistant 184A1L5(R) cells."
11940657
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"The proteins p27, CDK4, and cyclin D1 are associated with the cell cycle and proliferation [ xref – xref ]."
32206038
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"p16 dissociated cyclin D1-Cdk4 complexes with the release of bound p27(KIP1), while Cdk4(N158) formed complexes with cyclin D1 and p27."
9710613
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"While p27KD reduces the concentration of the assembled p27-cyclin D1-cdk4 ternary complex, removing PD’s target, it would also release cdk2, which has been shown competent to drive proliferation in the absence of cdk4 ( xref )."
29330290
sparser
"In addition, the binding of the CDK2 inhibitor p27 to CDK2 was decreased in AMBRA1 -knockout cells and cells expressing cyclin D1(T286A), and at the same time p27 was more abundantly bound to cyclin D1 and CDK4 ( xref , xref , xref )."
33854239
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"The interaction between p27 KIP1 , cyclin D1, and CDK4 was enhanced by galectin-3 depletion."
24971481
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"Hsc70 interacts with CDK inhibitor p27, which regulates the assembly and subcellular localization of cyclin D1-CDK4-p27 complex."
26481195
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"Interestingly, such phenomenon was not observed in the PDAC model (1222), further confirming that only a very small fraction of cyclin D1 and CDK4 could form complex with p27 due to its low baseline expression ( xref )."
33323381
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"In proliferating 184A1L5(R) cells, more p27 was associated with cyclin D1-cdk4 complexes than in 184(S)."
11940657
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"The interaction between p27 KIP1 , cyclin D1, and CDK4 was also decreased by galectin-3 overexpression."
24971481
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"Specifically, p21 Waf1/Cip1 binds to cyclin D1-CDK4 complex (at high stoichiometric ratios), and p27 Kip1 binds to cyclin D1 or cyclin D1-CDK4 complex, inhibiting their activity."
25609198
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"In mouse fibroblasts, p27 is associated predominantly with cyclin D1-Cdk4."
8033213
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"During this process, p27 Kip1 tightly binds to the cyclin D1–CDK4 complex and induces cell cycle arrest xref , xref ."
30770784
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"Immunoprecipitation experiments revealed that p27Kip1 preferentially associated with CdK4 in Ang II-treated LLC-PK1 cells and that the activity of this kinase was inhibited after Ang II-treatment, an effect that may be generated by increased p27Kip1 binding to cyclin D1-CdK4 complexes."
8943498
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"Similarly, IP with an anti-p27 antibody showed an interaction of p27 with cyclin D1 and CDK4 in both Fah/p53 -/- and in Fah -/- mice."
33484913
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"Nevertheless, this does not explain that the abundant p27 in G 0 cells is unable to assemble ectopically overexpressed cyclin D1 into CDK4 complexes in serum-starved fibroblasts [12] and, conversel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14597415
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"Moreover, co-treatment with IGF-I and FGF-2 increased cyclin D1 association of cdk4 and p27(Kip1) significantly compared to FGF-2 treated cells ( P ≤ 0.02)."
15033176
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"However, Src treatment led to tyrosine phosphorylation of p27 and catalytic activation of assembled cyclin D1-Cdk4-p27 complexes."
18710949
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"The results of the complex association analyses demonstrated that association of cdk4 and p27(Kip1) with cyclin D1 directly correlated with cyclin D1 induction."
15033176
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"P27, a key cell cycle protein kinase inhibitor, formed a complex with CCND1 and CDK4 that prevents CDK4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein and blocks the cell-cycle G1/S transition."
24359578
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"In conclusion, our results suggest that NBL1 could inhibit PDGF-BB-induced human PASMC proliferation, and the underlying mechanism is associated with the decreased cyclin D1–CDK4 activity and up-regulated p27 by decreasing the phosphorylation of p27 via blockade of PDGFRβ-p38MAPK signal cascade."
27474499
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"Together, these data indicate that the interaction of p21 with cyclin D1, CDK4, and CDK2, and the interaction of p27 with cyclin D1 and CDK4, is not impaired in Fah/p53 -/- mice."
33484913
bel
"This study aimed to determine the relative contribution of CDK inhibitors to these events. Following progestin treatment, the majority of cyclin E- and D-CDK complexes were bound to p27(Kip1) and few were bound to p21(Cip1)."
10713180
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"Altered phosphorylation of p27 in the resistant 184A1L5(R) cells may favor the binding of p27 to cyclin D1-cdk4 and prevent its accumulation in cyclin E1-cdk2 in response to TGF-beta."
11940657
sparser
"P27 binds to the Cdk4-cyclin D1 complex preventing phosphorylation of the retinoblastoma (Rb) protein and release of the elongation factor E2F. This prevents the transcription of many of the proteins required for the cell to transit the 'S' phase."
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