IndraLab

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USP10 activates cell migration. 3 / 3
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"Ouchida et al. (2018) identified that USP10 functions as a deubiquitinase and regulator of the EMT‐transcription factor Slug to promote cell migration in multiple tumor cells, including non‐small‐cell lung carcinoma, ovarian cancer, fibrosarcoma, and breast cancer."
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"Interesting, Spautin‐1 imposed minimal effect on the cell proliferation (Fig. S5C), suggesting that under our experimental conditions, USP10 mainly modulated cell migration rather than cell proliferation, through the regulatory effect on Smad4."
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"Figure 5B displays that depletion of endogenous USP10 with shRNAs markedly decreased cell migration compared to that of the control cells, as indicated by the inhibition rate on wound healing as 56.15%, 59.19%, and 76.42%, respectively (P < 0.001)."
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