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USP2 deubiquitinates Cyclin on D1. 5 / 5
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"reported that USP2 specifically deubiquitinates and stabilizes cyclin D1, whereas knockdown of this protease causes cyclin D1 degradation and growth arrest in cancer cells dependent on this cell cycle regulator."

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"In particular, it has been recently shown that USP-2 deubiquitinates cyclin D1, prevents degradation, accumulates cyclin D1 and finally leads to cell cycle progression from G1 to S phase (Lee et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Cyclin D1 ubiquitination is reversed by the deubiquitinases USP2 and USP22."

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"Several compounds have been shown to suppress the activity of USP2, which can promote the deubiquitylation and stability of cyclin D1 [137]."

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"In a screen of potential deubiquitination enzymes, Shan et al. identified USP2 to specifically deubiquitinate cyclin D1, preventing the degradation of cyclin D1, and leading to the accumulation of cyclin D1."