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TRIM72 decreases the amount of IRS1. 8 / 10
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"As expected, genetic deletion of MG53 in mice actually ameliorates the development of insulin resistance in skeletal muscles and increases the level of IRS-1, even when the mice are fed a high-fat and high sucrose diet."
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"Here, we demonstrate that MG53 induces IRS-1 ubiquitination with the help of the E2 enzyme UBE2H during skeletal myogenesis by examining MG53 disrupted skeletal muscle cells and tissues.|The IRS-1 protein level was decreased by MG53 in a concentration dependent manner and was restored by the addition of MG132, a proteasome inhibitor (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Moreover, MG53 disruption increases IRS-1 protein level in mouse skeletal muscles such as soleus and gastrocnemius-plantaris."
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"As evidenced by MyHC immunofluorescence, myogenic index and immunoblotting, MG53 knockout enhanced myogenesis by increasing the level of IRS-1 expression (XREF_FIG)."
23965929
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"In contrast, the IRS-1 expression level was decreased about 60% by MG53 but not by C14A or DeltaR in both C2C12 myoblasts and myotubes (XREF_FIG; XREF_SUPPLEMENTARY)."
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"The IRS-1 protein level was decreased by MG53 in a concentration dependent manner (XREF_SUPPLEMENTARY) and was restored by the addition of MG132, a proteasome inhibitor (XREF_FIG; XREF_SUPPLEMENTARY)."
23965929
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"The genetic disruption of MG53 increases IRS-1 levels, improves insulin signaling in mouse skeletal muscle and ameliorates insulin resistance in diet induced obese (DIO) mice XREF_BIBR, XREF_BIBR."
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"Studies have shown that genetic disruption of MG53 increases IRS1 levels, improves insulin signaling in skeletal muscle of mouse and insulin resistance in diet induced obese (DIO) mice [XREF_BIBR]."
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