IndraLab

Statements


RPN8 binds PSMD14. 5 / 5
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sparser
"In these processes, POH1 could be involved as part of proteasome subcomplexes (the 19S regulatory particle, the lid subcomplex or a POH1-Rpn8 MPN dimer)."

sparser
"Each of the above multiprotein complexes contains a single heterodimer of MPN proteins, usually with one catalytically active and one inactive monomer (POH1-Rpn8 in the proteasome, CSN5-CSN6 in the signalosome and BRCC36-Abraxas in the RAP80 complex)."

sparser
"Rpn8-RPN11 and CSN5-CSN6 heterodimeric states are shown in Figure xref ."

sparser
"Both complexes contain an MPN dimer (CSN5-CSN6 in the COP9 signalosome and POH1-Rpn8 in the proteasome lid) and six PCI-domain proteins."

sparser
"Some of the processes that are influenced by POH1 could be mediated by factors not affected by the main proteolytic activity of the 26S proteasome and involving the sole 19S regulatory particle or other POH1-containing subcomplexes (the proteasome lid or the POH1-Rpn8 dimer), although experimental proof of this concept is lacking due to the difficulty of separating proteasome binding from POH1 function."