IndraLab

Statements

TP53 binds MDM2 and lanA1. 6 / 6
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"They demonstrate that formation of the LANA, MDM2, and p53 complex is relevant to maintain viral latency [XREF_BIBR]."
27698494
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"Whether the LANA, MDM2, and p53 complex is preferentially involved in ORF50 degradation still needs to be further investigated."
27698494
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"Such results demonstrated that Nutlin-3 is able to disrupt the p53, MDM2, and LANA complex and to suppress the anti-apoptotic activity caused by the complex created by LANA, p53, and MDM2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29932446
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"The use of the MDM2 inhibitor Nutlin-3a disrupts the p53, MDM2, and LANA complex inducing a specific and highly potent activation of apoptosis in PEL cells [XREF_BIBR]."
27258263
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"In particular, it has been shown that the LANA/p53/mdm2 complex is crucial for PEL cell survival [38] ."
23999127
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"Our results demonstrated that the KSHV latency associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53, MDM2, and LANA complex and selectively induced massive apoptosis in PEL cells."
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