IndraLab

Statements

TP53 binds MDM2 and lanA1. 5 / 5
| 5
reach
"Such results demonstrated that Nutlin-3 is able to disrupt the p53, MDM2, and LANA complex and to suppress the anti-apoptotic activity caused by the complex created by LANA, p53, and MDM2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29932446
reach
"They demonstrate that formation of the LANA, MDM2, and p53 complex is relevant to maintain viral latency [XREF_BIBR]."
27698494
reach
"Whether the LANA, MDM2, and p53 complex is preferentially involved in ORF50 degradation still needs to be further investigated."
27698494
reach
"Our results demonstrated that the KSHV latency associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53, MDM2, and LANA complex and selectively induced massive apoptosis in PEL cells."
17364023
reach
"The use of the MDM2 inhibitor Nutlin-3a disrupts the p53, MDM2, and LANA complex inducing a specific and highly potent activation of apoptosis in PEL cells [XREF_BIBR]."
27258263